With Pikachu healed up, Ash decides to not return with his mom and Professor Oak to Kanto and to travel around the Unova region instead. As he begins his travels he meets a girl named Iris and together they decide to travel with each other, but when Pikachu and Axew are stolen by Team Rocket, will they be able to save their only Pokémon?
A young boy named Ash Ketchum embarks on a journey to become a "Pokemon Master" with his first Pokemon, Pikachu. Joining him on his travels are Brock, a girl-obsessed Rock Pokemon Trainer, and Misty, a tomboyish Water Pokemon Trainer who may have a crush on him. Ash and Co. end up traveling through various regions, including Kanto, the Orange Islands, and Johto, and then enter the Pokemon League competitions there.
Along the way, they run into many confrontations with Jessie, James, and Meowth, a trio of Pokemon thieves who are apart of an evil organization called "Team Rocket". But every time Team Rocket try to do their evil deeds, they fail thanks to Ash and his Pokemon.