While taking a break on their journey, Ash and friends come under attack by wild Pokémon and the gang's Pokemon are badly poisoned. The only thing nearby that can heal them are herbs found at the bottom of a nearby lake. However, when Oshawott goes to get them, it is attacked by a wild Palpitoad and Stunfisk. Now everyone must find a way to stop the two Pokémon and heal the gang's Pokemon.
A young boy named Ash Ketchum embarks on a journey to become a "Pokemon Master" with his first Pokemon, Pikachu. Joining him on his travels are Brock, a girl-obsessed Rock Pokemon Trainer, and Misty, a tomboyish Water Pokemon Trainer who may have a crush on him. Ash and Co. end up traveling through various regions, including Kanto, the Orange Islands, and Johto, and then enter the Pokemon League competitions there.
Along the way, they run into many confrontations with Jessie, James, and Meowth, a trio of Pokemon thieves who are apart of an evil organization called "Team Rocket". But every time Team Rocket try to do their evil deeds, they fail thanks to Ash and his Pokemon.