Ash and his pals come to a Pokemon Centre in a quiet little forest when they encounter two Chanceys and someone wearing a scuba suit, that person appears to be Nurse Joy! But she is different from all the other Nurse Joys, because this Nurse Joy is great at handling Water Pokemon, and Misty is excited to meet her but what will she expect?
A young boy named Ash Ketchum embarks on a journey to become a "Pokemon Master" with his first Pokemon, Pikachu. Joining him on his travels are Brock, a girl-obsessed Rock Pokemon Trainer, and Misty, a tomboyish Water Pokemon Trainer who may have a crush on him. Ash and Co. end up traveling through various regions, including Kanto, the Orange Islands, and Johto, and then enter the Pokemon League competitions there.
Along the way, they run into many confrontations with Jessie, James, and Meowth, a trio of Pokemon thieves who are apart of an evil organization called "Team Rocket". But every time Team Rocket try to do their evil deeds, they fail thanks to Ash and his Pokemon.