Proof centers on Dr. Carolyn Tyler, a skeptical, hard-science, brilliant surgeon with a caustic edge who has been struggling with the devastating loss of her teenage son and a growing estrangement from her surviving daughter. She is persuaded to investigate cases of reincarnation, out-of-body experiences, hauntings - all of it looking for verifiable proof to answer one of life's greatest questions: Is passing truly the end, or is there something else beyond?