The Conner family is thrown back together in a haze of blood and confusion, as prodigal son Griffin returns to his second family home - Bethune General Hospital.
Griffin's first day as Bethune's newest porter is a rocky one, while Melissa forges an unlikely connection with the sister of a patient whose life she is scrambling to save.
Brian resolves to improve his patient interaction after receiving several complaints, while Griffin forms an unlikely bond with a cantankerous war veteran. Dr. Tuttle refuses to consider Sandy's diagnosis of a rare disease in a dancer.
When two babies die of a mysterious infection in the Paediatric ICU, Allen scrambles to find patient zero before Bethune General suffers a full-blown outbreak.
Bruno shocks everyone by making an obscure diagnosis that saves a patient's life, and a momentous secret from his past is revealed. After being kicked by a patient, Sandy calls Melissa for help instead of Brian.
An offhand comment from Allen sends Melissa into a tailspin, while Brian desperately tries to atone for a past mistake. Natasha is back to get in between Zoe and Griff.
When Rebecca is brought into the ER with a mysterious paralysis creeping up her body, Allen has to scramble to find out what's happening before it's too late.
Griffin starts to spin out of control after a harrowing car accident evokes a traumatic event from his past and Bruno gives Mel some vital tips on purse string suturing.
A tumultuous day at the hospital gives way to an awkward dinner with Brian's family, leading to an astonishing revelation for Sandy... And Griff winds up with a black eye.
Sandy struggles to say goodbye to Brian as her reconfigured family rally around to support her.