On her sixteenth birthday, Sabrina Spellman finds out that she is a witch. However, instead of helping her, it actually makes life more difficult, especially after she gets on the wrong side of head cheerleader, Libby.

In order to find out what Libby has been saying about her and Jenny, Sabrina gives her a piece of cake covered with truth sprinkles. However, when her teacher shares the cake with students and teachers, Sabrina finds that the truth hurts

In an attempt at earning some money to buy roller blades, Sabrina takes a job babysitting a little boy. However, when she is trying to calm him down, she inadvertently casts a spell which turns him into a man.

Sabrina makes three wishes come true for her unsuspecting friends: Jenny gets elected student president, Harvey becomes a football star, and Mr. Pool becomes rich (by discovering how to change lead into gold). But she soon learns the truth of her aunts' warnings that one shouldn't meddle with the fate of others: Jenny is crushed when she learns the student president is merely a rubber stamp assistant to the principal, and resigns in favor of Libby, Harvey really can't play football and is injured on the field, and Mr. Pool's success at alchemy turns him into an obnoxious blowhard. Sabrina is faced with the ominous task of explaining her error to the Witches' Council. Meanwhile, Salem must perform community service as part of his sentence.

Sabrina is forced to attend a family affair on Halloween, so she sends a clone of herself to a party she was supposed to attend. Unfortunately, the simple-minded clone agrees with everything anyone suggests, which eventually leads to her streaking through Harvey's backyard. Meanwhile, the real Sabrina tries to ditch her snobby cousin Marigold and her bratty daughter Amanda (Emily Hart), and later gets a heartwarming surprise when she discovers that as a witch, she can talk to a deceased loved one for an hour on Halloween night.

When Sabrina is left feeling down because Harvey has agreed to go to the school dance with Libby, her aunts literally cook up a date for her, but nonetheless she still pines for him.

Sabrina's zany Aunt Vesta pays her a visit and soon hatches a plot to entice her niece into moving to the Other Realm.

In an effort to get Harvey's attention, Sabrina takes a job as a magician's assistant, but things go awry when she inadvertently makes the magician disappear.

Sabrina, tired with Libby's constant teasing, turns her into a nerd to show her what it feels like to be picked on. But instead of learning a lesson, Libby shows her true colors and takes over the Science Club, making them into a group of jerky teens who look down on everyone else (just like her old cheerleading squad). To solve the problem, Sabrina uses a similar spell to turn the whole student body into nerds, keeping Libby from enjoying her prestigious position.

Sabrina learns a hard lesson in witchcraft when she tries to make Harvey notice her by using her powers to become an instant kung-fu expert under Mr. Pool's astonished tutelage. She easily defeats the standing champion, but must face the disapproval of her aunts and the jeers of the (magically animated) trophy she won. Meanwhile, Aunt Hilda tries out for first violin in the local symphony the mortal way, but loses to her longtime rival Gustav.

After Salem stows away in her backpack and gets her thrown out of the local pizzaria, Sabrina washes her hands of the cat, feigning unconcern when the feline fails to return for Christmas dinner with visiting cousin Monty. When she discovers that Salem has in fact been catnapped by a stubborn little boy named Rex, Sabrina launches a desperate plan to rescue him by impersonating Santa Claus.

When Sabrina's bitter math teacher Mr. Rothwell singles her out for unfair treatment, and her aunts are unable to make him see reason, the witchly trio decide it's time to teach him a few of their own spellbinding lessons. When he's hauled into traffic court, they replace the human judge with a magical substitute who's been hibernating in a deep freeze "to prevent media bias". Meanwhile, Salem panics when his ex-girlfriend decides to pay him a surprise visit - especially since she has no idea that he has been turned into a cat.

When Sabrina is apprehensive about inviting Jenny to spend the night because of her "unique" home life, Hilda and Zelda assure her that she has nothing to worry about. But when Jenny accidentally enters the other realm through the linen closet, Drell cites the rule against mortals entering his world and turns her into a grasshopper, so Sabrina and her aunts must find a way to convince her that the whole experience was just a dream. (They get help from the official Rules Keeper, who cites the rule that "Every rule must have a loophole".)

A stressed-out Sabrina gets a monstrous wart, which only worsens her foul mood. And despite everyone's efforts to cheer her, she seeks solace and solitude in an alternate world inside her mirror, where she becomes trapped in her own bad mood. Baltimore Oriole Brady Anderson appears as himself to guide her through the realm of making amends - to Jenny for ignoring her, to Harvey for ridiculing his use of a puppet spider monkey to get them through a school assignment she flubbed, and to Libby for turning her into a goat. In the end, she endorses Aunt Hilda's recipe for a good time - a gigantic flan.

When Sabrina is disappointed that her aunts won't let her stay out late to see a famous rock band (Violent Femmes), Hilda and Zelda decide to transform themselves into teenage chaperones as a compromise. But they're the ones causing the trouble when "Hillary" clashes with a security guard (played by Bubba Smith) and a high-school boy falls for "Zellery". After proving that even teenage aunts can be embarrassing, they apologize by giving Sabrina her very first flying lesson - aboard a vacuum cleaner.

A starry-eyed Sabrina hates to leave Harvey for a family skiing trip to Mars, but Doug, the good-looking and magically talented ski coach she meets there, soon has her forgetting to phone home while they spend a romantic evening together. Meanwhile, Hilda meets a man who claims to be a secret agent on a dangerous mission, which she assumes is just another holiday-on-Mars fib; and Salem takes the opportunity to host a riotous cat party at home.

A Valentine's Day episode shows that while dating is tough when you're a teenager, it's even tougher when you're a teenage witch. Just as Sabrina and Harvey are about to share their first kiss, Salem desperately interrupts them. Sabrina's cat isn't trying to be a pest, and no, he's not jealous; rather, the feline knows that a kiss from Sabrina will turn Harvey - or any boy for that matter - into a frog. In order to reverse the tragic spell, Sabrina must pass the Witches' Council's "Test of True Love" to prove that her feelings for Harvey are genuine; and Hilda takes the opportunity to demonstrate the depth of her attachment to Drell (rather less successfully).

Hoping to encourage more students to join the Adopt-A-Grandparent program, Sabrina finds a mischievous way to get trend-setting Libby to participate: she impersonates her, necessitating quick Superman-style telephone booth transformation whenever the (increasingly puzzled) real Libby turns up. But Sabrina's well-meant scheme goes wrong when Libby bonds with Sabrina's adopted grandmother Nana, who claims to know most of Hollywood's young hunks personally. Meanwhile, Zelda can't decide whether to continue dating a man who is centuries younger than she is; and Hilda and Salem eat too much of a magical "hair soup" that causes their hair to grow at an exponential rate.

Sabrina has blown her allowance, and Salem has maxed out his credit card over the phone, so they decide to enter a cat show to earn the prize money, but soon find themselves wrapped up in a blackmail scheme to force the judge to throw the competition, and, to avoid being caught, Sabrina has to transform herself into a contestant. Meanwhile, Hilda and Zelda seek out a magical perfume that will make Zelda repulsive to their love-sick mailman Dirk, and Hilda gets shrunk as a punishment for taking free samples in the magical "Full Moon" shop.

Preparing for her father's monthly visit, Sabrina anticipates the teenage trauma of introducing her father to her boyfriend (actually, Edward and Harvey do reasonably well), but isn't prepared for the teenage trauma of meeting your divorced father's new girlfriend, an attractive supernatural lawyer named Gail. Initially hostile, Sabrina is persuaded by her aunts to see reason and tries to make amends by asking whether Edward and Gail plan to get married. When they simultaneously answer "Yes" (Gail) and "No" (Edward), Gail furiously dives into Sabrina's magic book. Attempting to follow, Sabrina must appeal to the magical Index Man to help her locate Gail's page (presumably the equivalent of using a search tool to find a web page), and tries to persuade Gail that Edward is still traumatized by his divorce and needs more time to consider commitment. Relenting, Gail rejoins the family game of magical charades.

A bored Sabrina gets more than she bargained for when Hilda offers her a "can of worms" spell to spice up her daily grind, which is transformed into a melodramatic soap opera. When a mysterious one-eyed janitor accidentally beans Harvey with a ladder, Sabrina's sweetheart wakes up with amnesia, and a dastardly Libby seizes the chance to steal him, convincing him that he has agreed to kiss her publicly at the climax of the school fashion show; Libby also steals the diamond ring Mr. Poole is about to offer the buxom school nurse and plants it on Sabrina, who must enlist her aunt's help to demonstrate her innocence before the spells runs its narrative course. A chastened Sabrina joins Salem in the less hazardous hobby of watching floating lint.

Sabrina hits a really bad day: disregarding her aunts' warning, she buys a "tomorrow" ball from a supernatural traveling salesman, and believes its prediction that she will get an "A-" on her science project. Unfortunately, Mr. Pool (dressed in a kilt for "Scots Pride Day") doesn't share that estimation of her work, and gives her a C- and a chance to redo the project overnight. Instead, Sabrina tries to sneak out of the house aboard her trusty vacuum cleaner to attend a "Smashing Pumpkins" concert, but gets pulled over by a flying motorcycle cop and cited for flying over the town "with a full bag and bad dust emissions". An abashed Sabrina shrinks to miniature size as a result of guilt; to cheer her up, her aunts share stories of how they have "messed up" over the centuries - including the hitherto unheard story of Zelda's literally middle-aged marriage to one Benvolio. In a related subplot, Salem visits his witchly parole officer, and pleads that his rehabilitation is going well, but

Sabrina's fears become reality when she takes part in a re-creation of the Salem witch trials and is accused of sorcery while defending Jenny's honor.

When Sabrina can't find her homework, she follows Salem's advice to consult a professional magic finder, but when troll Roland appears and quickly uncovers her missing notebook, he demands her hand in marriage as payment. Following him home to attempt reason she is trapped in his castle and can only be rescued by the prince she loves: Harvey. Has the moment come when he will learn the truth about Sabrina's unusual family? Meanwhile, her aunts try to break the contract with the help of a witchly lawyer "with great legs".