It's Andrea's wedding day! While Andrea has chosen her life partner, Samantha has to make a decision as to who she wants to be with. Will it be debonaire millionaire Winston Funk or her not-rich-but-ever-reliable ex-boyfriend Todd. Even Sam's parents are at a crossroad as Regina and Howard begin to take separate paths.
Samantha "Sam" Newly is left in a coma for a week following a terrible accident. When she awakes, Sam has no memory of any past experiences or events and must start her life over.
However, Sam quickly discovers that instead of being a good-hearted person, she was self-centered, narcissistic, and failed to have any real relationships - a person that most people disliked. Now, faced with amnesia, Sam must try to right her wrongs and struggle with the desire to regress back to her old ways.
Starting over and drawing the line between good and evil proves harder than Sam ever thought.