Dr. Helen Magnus and the team are still recuperating from the Cabal attacks that devastatingly took down so many Sanctuaries around the world.
Magnus and Druitt struggle to come to terms with the apparent passing of their only daughter, Ashley. Druitt seeks revenge on her captor, the Cabal. Magnus, however, clings to the faint hope that Ashley could somehow still be alive. While Druitt leaves to exact his bloody revenge, Magnus takes a quiet, methodical approach to prove that Ashley is alive.
Meanwhile, Will, Henry, and Bigfoot take on the daunting task of organizing and processing the hundreds of Abnormals who survived the worldwide attacks, but now seek refuge at their Sanctuary.
Kate, not quite ready to give up her life as a petty thief and swindler, makes a bold move to cash in on a rare Abnormal species that has been delivered to the Sanctuary. With a quick phone call, she's worked up a deal, certain to catch a hefty sum. But as she prepares to capture her "windfall," the Abnormal escapes, sending her, along with an unimpressed Henry, on an adventurous hunt through the city for the runaway.
With all the chaos around them, the Sanctuary team must come to terms with how to rebuild after the Cabal's attacks.
Season 2 Episode 3 of Sanctuary resulted in a 0.00 rating in the 18-49 demographic.
Dr. Helen Magnus is one of the first female doctors in the Royal College during Victorian England. She was engaged to Jack the Ripper, and also has a daughter from him, Ashley. However, Ashley does not yet know that her father is Jack. Dr. Magnus' father started a sanctuary for supernatural creatures, collected from all over the world. In her work with these creatures, Dr. Magnus has received age longevity. While tracking a dangerous young man she crosses paths with a young psychiatric resident Dr. Will Zimmerman who may have what it takes to become her new protégé.