When Alex's brother Luke is admitted to Hope Zion Hospital in critical condition, Joel and Charlie must work together to keep him alive while keeping his admittance a secret from Alex. Meanwhile, Alex figures out a way to remove a tumour from a patient pregnant with twins, while Maggie is thrown off her game by the patient's gorgeous OB/GYN.
When charismatic Chief of Surgery Charlie Harris at Toronto's Hope-Zion Hospital ends up in a coma, he leaves the hospital in chaos - and his fiancee and fellow surgeon, Alex Reid, in a state of shock. Along with newly-arrived star surgeon, Joel Goran, Alex races to save Harris' life.
As the action unfolds, comatose Dr. Harris explores the hospital halls in "spirit" form, not sure if he's a ghost or a figment of his own imagination. Reid, along with her fellow doctors, press on to save his life and those of their other patients, as they deal with the complicated and courageous decisions that are made in their daily struggle to keep hope alive.