Alex is surprised twice in one night - first when she realizes she's been tricked into a blind double date, and again when she has to rush her mystery man to the ER. Meanwhile, Charlie works to help a soldier move past a traumatic experience, and Maggie discovers a patient has a contagious illness that could put her pregnancy at risk.
When charismatic Chief of Surgery Charlie Harris at Toronto's Hope-Zion Hospital ends up in a coma, he leaves the hospital in chaos - and his fiancee and fellow surgeon, Alex Reid, in a state of shock. Along with newly-arrived star surgeon, Joel Goran, Alex races to save Harris' life.
As the action unfolds, comatose Dr. Harris explores the hospital halls in "spirit" form, not sure if he's a ghost or a figment of his own imagination. Reid, along with her fellow doctors, press on to save his life and those of their other patients, as they deal with the complicated and courageous decisions that are made in their daily struggle to keep hope alive.