Alex is on her way home to unwind after a long day at work - but all that changes when she witnesses a traumatic accident and is forced to return to work, where the Hope Zion Hospital doctors must work tirelessly against the clock to save a problematic John Doe. Meanwhile, Charlie and Gavin explore Charlie's relationship to the Spirit World in a therapy session.
When charismatic Chief of Surgery Charlie Harris at Toronto's Hope-Zion Hospital ends up in a coma, he leaves the hospital in chaos - and his fiancee and fellow surgeon, Alex Reid, in a state of shock. Along with newly-arrived star surgeon, Joel Goran, Alex races to save Harris' life.
As the action unfolds, comatose Dr. Harris explores the hospital halls in "spirit" form, not sure if he's a ghost or a figment of his own imagination. Reid, along with her fellow doctors, press on to save his life and those of their other patients, as they deal with the complicated and courageous decisions that are made in their daily struggle to keep hope alive.