Alex is trying to get her life back to normal with Charlie and at Hope Zion Hosital - but with Charlie's head in the clouds and the pressure to find her medical niche - she's struggling. Inspiration comes in the form of an immigrant doctor who needs Alex to save his wife's life,
and in return, helps her find her calling.
When charismatic Chief of Surgery Charlie Harris at Toronto's Hope-Zion Hospital ends up in a coma, he leaves the hospital in chaos - and his fiancee and fellow surgeon, Alex Reid, in a state of shock. Along with newly-arrived star surgeon, Joel Goran, Alex races to save Harris' life.
As the action unfolds, comatose Dr. Harris explores the hospital halls in "spirit" form, not sure if he's a ghost or a figment of his own imagination. Reid, along with her fellow doctors, press on to save his life and those of their other patients, as they deal with the complicated and courageous decisions that are made in their daily struggle to keep hope alive.