After being cuddled in the heart, Dr. Alex Reid has a profound experience in the liminal space, while a desperate Charlie Harris and his ex - Dawn Bell race against the clock to save her life. Meanwhile, Dr. Joel Goran is pulled in to the ER to treat a suicidal patient that tests his duty as a doctor, and Maggie Lin makes a bold decision that changes her relationship with Gavin Murphy.
When charismatic Chief of Surgery Charlie Harris at Toronto's Hope-Zion Hospital ends up in a coma, he leaves the hospital in chaos - and his fiancee and fellow surgeon, Alex Reid, in a state of shock. Along with newly-arrived star surgeon, Joel Goran, Alex races to save Harris' life.
As the action unfolds, comatose Dr. Harris explores the hospital halls in "spirit" form, not sure if he's a ghost or a figment of his own imagination. Reid, along with her fellow doctors, press on to save his life and those of their other patients, as they deal with the complicated and courageous decisions that are made in their daily struggle to keep hope alive.