While old acquaintances become teachers, new students are introduced at Sacred Heart.

Luca learns her first hard lesson in being a doctor.

J.D. learns a lesson in teaching, when Dr. Cox and Lucy reverse their roles of teacher and student.

J.D. and Turk have time to party, when their wives are out of town.

J.D. still clamors for Dr. Turk's approval as he approaches his final day of teaching at Sacred Heart, Lucy searches within herself for the courage to perform a basic medical procedure on a real human, and Denise and Drew make things official.

Elliott offers some advice and guidance to an over-worked and exhausted Lucy, while Turk struggles to find a replacement best friend.

The medical students of Winston University must first figure out why they really want to be doctors before they can get their white coats. Meanwhile, Denise gets a few relationship advices from Elliot.

Lucy finds couplings, dysfunctional or not, throughout the hospital.

J.D. and Elliot start to settle in when they are getting a baby, while Lucy experiences problems with the reality of operating on people.

The medical school is plagued when a case of guilty conscience occurs after a student cheats on an exam and Dr. Cox takes it out on the entire class. Meanwhile, Denise makes a surprising admission of her own.

Dr. Turk feels threatened when an internationally renowned surgeon comes for a visit, while Lucy takes the new job of team leader a bit too seriously.

When Cole and Kelso both get negative results back after a few routine tests, they learn the hard way to put their egos in check in order to rein in the support of their so-called friends.

The med students of Winston University finally find something to be thankful for when Cole identifies his true calling in surgery, Drew finds the love of his life, and Lucy finds the inspiration to become a doctor.