Chicago EMT's and longtime best friends Johnny and Hank are breaking in Brian, an eager new recruit. Johnny's on again-off again relationship with Theresa, a cop with Chicago PD, is the main topic of the day. Hank implores him to move on, especially when he sees Theresa flirt with her new partner Danny, who Hank calls a dead ringer for Denzel Washington. But Johnny's not ready to let go, even though it was his inability to commit that drove Theresa away. And when he finds out that she has a date that very night, he enlists Hank and a reluctant Brian to help him with a stakeout.

Johnny and Hank decide to teach a CPR class to kids as a way of building up good karma. The plan seems to have immediate benefits as they receive prime football tickets as thanks from a victim, but things quickly go awry.

Trying to be good guys, the guys return to a patient's house to clear the history from his computer and end up seeing something that may scar them for life. The situation reminds Johnny that the iPad he loaned to Theresa has porn on it.

A dying man's last words inspire Johnny to have the first conversation he's had with his dad in seven years. Elsewhere, a determined Brian takes Hank on a quest to communicate the dead man's final message to a long lost love.

Johnny and Theresa decide to be "friends with benefits", despite the other EMTs misgivings. Brian treats a victim impaled with a lawn jart, bringing him closer to completing his EMT bucket list.

Johnny decides the time is right for Theresa to meet his father, but his dad has one more surprise for him. Brian looks to get closer to Voodoo despite Johnny and Hank's warnings. Hank asks Cash to be his wingman at dinner with his mother.

Hank gets invited to the wedding of an ex and Johnny gives him his support. Theresa and Brian attend the wedding to get the scoop for Hank and end up in an unusual confrontation.

After it's revealed that Hank is passingly afraid of spiders and Brian comes face-to-face with his suicidal doppleganger, everyone examines their own fears, and Johnny gets payback for all the practical jokes he's played.

While teaching a class to prospective EMTs, the crew recalls a day that ran the gamut from the mundane to the catastrophic, and Johnny tries to find out who ate last the donut.

Theresa has a brush with passing on the job and resolves to join the FBI in Washington. When Johnny proposes marriage to keep her in Chicago, they must overcome a series of catastrophes and mishaps to get to the altar.