Quinn and Rembrandt head down to Mexico to blow off a little steam. Getting back into the United States turns out to be a bit of a problem when they get mixed up in an illegal snake trade and find themselves stuck in the middle of a jungle, surrounded by deadly snakes and the tobacco cartel. Meanwhile, Wade and Maggie run into problems of their own while they search for the other Sliders.
In his basement in San Francisco, boy-genius Quinn Mallory unlocks the doorway to an infinite number of Earths. During a test run, Quinn invites co-worker Wade Wells and his teacher Professor Maximillian Arturo to see his new invention. But an increase in power and an early departure leave all three, plus a washed-up soul singer named Rembrandt "Crying Man" Brown, lost in a parallel world. Now they must "slide" from world to world, not only adapting to their changing surroundings, but also trying to get back to their world. Will they ever make it home?