While on a biosurvey mission in the Gamma Quadrant, Doctor Bashir, Commander Dax, and Major Kira receive a distress signal on their Runabout from a planet. Arriving, Bashir and Dax beam down to a world of people slowly dying from an illness that begins at birth and eventuallyhugs them, a virus given to them by the Dominion for defying them. The Federation members stay in order to help find a cure for the planet.
When the Cardassian occupation of Bajor ended in 2369, the mining space station Terok Nor was left abandoned, its systems ripped out. By invitation of the Bajoran provisional government, Starfleet stepped in to oversee the rebuilding and day-to-day operations of the newly christened Deep Space Nine.
The years of Starfleet's nonintervention into Cardassian matters, however, had taken its toll on relations with the Bajorans. Consequently, Starfleet's position was a tenuous one; many Bajorans, suspicious and hostile as a result of decades of Cardassian oppression and brutality, did not greet the Federation's presence with open arms. The Federation's assistance is put to the test as DS9 becomes a center of travel and commerce that stretches into the Gamma Quadrant.