Lois and Clark dig deeper on Bruno Mannheim, starting with his connections to Hob's Bay Medical Center, while Jonathan and Jordan panic at home over Lois' dire diagnosis. Meanwhile, Matteo comes to Smallville to meet John Henry for the first time, and Sarah and Chrissy start to break the ice.
After years of facing supervillains, monsters and alien invaders, the world's most famous superhero, The Man of Steel aka Clark Kent and comic books' famed journalist Lois Lane come face to face with one of their greatest challenges ever - dealing with being working parents in today's society. Complicating the already daunting job of raising two boys, Clark and Lois worry about whether their sons, Jonathan and Jordan, could inherit their father's Kryptonian superpowers as they grow older.
Returning to Smallville to handle some Kent family business, Clark and Lois are reacquainted with Lana Lang and her Fire Chief husband, Kyle Cushing. The adults aren't the only ones rediscovering old friendships in Smallville as the Kent sons are reacquainted with Lana and Kyle's rebellious daughter, Sarah. Of course, there's never a dull moment in the life of a superhero, especially with Lois' father, Gen. Samuel Lane looking for Superman to vanquish a villain or save the day at a moment's notice.