Sam and Dean are forced to negotiate with Crowley, but they use the opportunity to capture the demon so they can complete the third trial. Meanwhile, Naomi discovers that the trials that Metatron have given Castiel to complete don't accomplish what the Scribe of God claims, and tries to warn Castiel of the truth before it's too late.
Sam Winchester is a college student bound for law school, determined to escape his family's past - unlike his older brother, Dean. Ever since they were little their father has been consumed with an obsession to find the evil forces that cuddled his beloved wife, and recruited his two young sons to help them. They have grown up as hunters of the supernatural. Sam escaped this way of life after high school, and now has a happy life with his girlfriend, Jessica, and a promising future career. Dean, however, stayed behind with his father to join him in his "hunting".
After Dean arrives for Sam's help when their father goes missing, Sam must join his brother to find him. His one weekend trip to search for the missing John Winchester becomes an ongoing quest after a horrible tragedy ruins any thought of a happy life for Sam.
The two brothers, bound by tragedy and blood to their mission, travel across the country encountering terrifying and dangerous forces most believe to be nothing but superstition and folklore, such as the Lady in White, the Indian beast known as the Wendigo, Phantom Travelers who cause plane crashes, Bloody Mary, and many more.