Raphael, Donatello and Mira continue to be trapped by constant sandstorms throughout the desert, but are saved by none other than Chompy Picasso, whose physical self has grown considerably over the decades. On their way, they manage to find "the Holy Chalupa" who is, in truth, an elderly thin Michelangelo himself. He takes them to his home of pizza, where Ice Cream Kitty waits. While, the three Turtles are catching up and trying to accept the loss of their leader and eldest brother Leonardo, they are all attacked by Verminator Rex who abducts Mira but is followed by an angry Raphael.
The turtles emerge from their hidden lair in the sewers for the very first time, ready to confront the wondrous and hostile world of New York City and face enemies more dangerous and pizza more delicious than anything they could have imagined. Along the way, they gain a friend in the fiesty teenage April O'Neil and gain enemies in the form of The Foot, The Shredder, and the alien Kraang.
Funnier and ninja-ier than ever before, the show will explore the camaraderie of four teenage brothers learning to rely on themselves and one another as they unravel the mystery of their existence and grow to become the heroes they are destined to be.