People begin to see their greatest fears - from tarantulas to walls closing in - leading Tom and Diana to look for someone with the ability to make people see only their worst fear. Their investigation finds that several of the victims used the same ATM before the 'fear attacks', leading them to a bank. Isabelle could land herself a better living situation if she agrees to be injected with Promicin.
The 4400 tells the stories of 4,400 people who disappeared over a period of fifty years and who all reappear at the exact same time without any memory of where they've been and what happened to them. Some of them have been altered and have strange abilities, both good and bad.
The series kicks off with a ball of light sailing toward Earth, but rather than the expected catastrophic event, thousands of people emerge from the ball of light. The returnees have been missing from a few years to several decades and no one has aged a day.