Rachel continues to seek information regarding the virus, while also managing an alarming situation in Lily's life. Meanwhile, Zach is under scrutiny at the CDC.
The series follows the lives of two neighbors, Rachel and Lily, as they embark on unprecedented times when a deadly new strain of a virus arrives. Navigating the new normal in New York City, Rachel works from home juggling her many telemedicine clients and a shaky marriage to her husband Dr. Zach, who has a prestigious job at the CDC miles away. Meanwhile, Lily is upstairs trying to convince her Wall Street clientele that her very specific skillset is still just as valuable through a video screen as it was in person.