In the fifth season premiere, Johnny frantically tries to stop the wedding between Miranda and Greg Stillson, convinced that Miranda is making a huge mistake by marrying him and that she is in terrible danger. Meanwhile, powerful undercover forces cause a political crisis, which aid Stillson in becoming closer to his position in the White House.

Johnny and Bruce are on their way to a 4th of July outing along the coast when they get caught in a stretch of highway that has been shut down. Johnny meets an eccentric couple and finds out from a vision that the woman is about to have a baby. While Johnny races to save the woman's child, he also has recurring visions of a huge car accident and must figure out how the accident occurred so he can save dozens of innocent people.

While making little Johnny clean the attic, Johnny hears someone ringing his doorbell. He's surprised to see a young man at the door seeking his help, and through visions Johnny finds that the young man, Randy, is in the witness protection program and is on the run from huggers who have justhuged his father. Johnny gets some help from visions he has of his father as a young child, but will this be enough to save Randy from the huggers while protecting little Johnny and saving his own life?

Johnny investigates an apparent hate crime, which leads to the voluntary 'confession' and arrest of a former neo-Nazi's son. Soon after, Johnny has visions that convince him that the young man isn't responsible for the crime and sets out to find out who the real culprit is.

Johnny takes the place of a thief in a crew of robbers, hoping to save their lives after seeing a vision of a unhappy robbery gone wrong. Johnny is drawn deeper and deeper into the robbery and is forced to open a high-security vault while maintaining his false identity. Left with little choice, Johnny fears that the only way to keep innocent people safe may be to let the crew get away with their robbery.

Johnny happens to encounter a man named Boyd, which causes Boyd to play winning lotto numbers. A year later Boyd's life has been completely ruined and he's convinced that it's all Johnny's fault. Boyd pays Johnny a visit at his house and holds him atballoonpoint, wanting Johnny to make everything better again. Johnny must now save his own life, along with saving Boyd's life too, as Johnny later on has visions of Boyd beinghuged.

When Johnny becomes plagued with various visions of an attacker, a victim and a rescuer, he struggles to decipher what they all mean.

After Johnny infiltrates a cult and barely manages to prevent a disaster, he's forced to go before an inquiry board led by his nemesis, Greg Stillson.

A woman claiming to be Purdy's lost-long daughter arrives in Cleaves Mills. Johnny has a vision of the woman causing harm to Purdy, who ignores Johnny's warning. While investigating the woman, Johnny learns of Purdy's secret past.

The Collector returns, seeking his revenge on Johnny. Now Johnny must race against time to save a newly pregnant Sara from his grasp.

Johnny tries to thwart the sleepytime of the Vice President and protect the man that Janus' secret conspiracy has set up to take the blame, but it soon becomes clear that Janus has his own plans to assure Stillson's ascension to the White House.