Thackery enlists Edwards to help him test a new hypothesis. After rejecting Robertson's advances at The Knick, Lucy learns that confession isn't always good for the soul. Young journalist Genevieve Everidge works on a story about one of Thackery's rivals. Cornelia is dismayed by the limits of her husband's sympathies. Barrow faces a new adversary at Tammany Hall. Gallinger is intrigued by a discussion of eugenics at a class reunion. Edwards deals with a surprise visitor.
The setting: downtown New York in 1900, a tumultuous time of massive change and great progress. The series centers around the groundbreaking surgeons, nurses and staff at Knickerbocker Hospital, who are pushing the bounds of medicine in a time of astonishingly high mortality rates and zero antibiotics.
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