As part of Channel 4's annual Stand Up to Cancer campaign, hosts Adam Hills, Josh Widdicombe and Alex Brooker and guests Kathy Burke and Harry Hill help raise awareness for Cancer Research UK. Plus, the usual comic review of the significant moments of the past seven days as the UK continues its rollercoaster ride towards Brexit. As usual, the hashtag #isitok paves the way for the gang to round up, examine and explain the leading and most entertaining news stories of the week.

Jimmy Carr joins Adam Hills, Josh Widdicombe and Alex Brooker to pick over the week's news.

Adam Hills, Josh Widdicombe and Alex Brooker are joined live in the studio by comedian and actors Aisling Bea and Nish Kumar.

Joe Lycett and Daisy May Cooper join Adam Hills, Josh Widdicombe and Alex Brooker to pick over the week's topical stories.

Kevin Bridges and Victoria Coren Mitchell join Adam Hills, Josh Widdicombe and Alex Brooker in this show to pick over the topical stories of the week.

Richard Ayoade joins Adam, Josh and Alex to take a view on the week's big stories.

Adam Hills, Josh Widdicombe and Alex Brooker are joined by a Stacey Dooley, Noel Fielding and Jamali Maddix in an extended special episode taking a sideways look at the upcoming General Election. The trio are joined by special guests to scrutinise the last-ditch attempts by parties to get voters on board, making their final predictions on the outcome and encouraging viewers to get out and vote.

On the day after the British public have cast their votes in the third election in four years, Adam Hills, Josh Widdicombe, Alex Brooker and their guests analyse the results, look back at the highs and lows of the campaign and do their best to make sense of the chaos the election has left behind.

Adam Hills, Josh Widdicombe and Alex Brooker pick over the week's biggest stories with Lorraine Kelly and Tom Allen.

Adam Hills, Josh Widdicombe and Alex Brooker, along with a host of celebrities including Sue Perkins, Sara Pascoe, Tom Davis, Rosie Jones and Johnny Vegas celebrate the arrival of a new decade and look back at 2019.