TC and Topher rush to the scene of a concert where a fireworks explosion has caused massive chaos. As the two jump in to manage the mess, a second explosion causes problems for one of our own. Syd, returns from Afghanistan and helps out with the team at San Antonio Memorial but finds herself grappling with best plans for herself and her young daughter. Drew tries to help but runs afoul of their unique family dynamic. Paul and Shannon put aside their differences to treat a patient and find they have more in common than they thought. Meanwhile, Jordan and Scott treat a patient injured in the fireworks explosion and have a chance to address some simmering differences.
Welcome to the night shift, where every day is a fight between the heroic efforts of saving lives and the hard truths of running a hospital. At San Antonio Memorial, the men and women who work the wee hours are a special breed, particularly adrenaline junkie T.C. Callahan. After a grueling tour of duty in the Middle East, T.C. is about to learn that his toughest battles will be fought right at home. He and his irreverent team of late-night docs, including Topher and Drew, know how to let off steam with the casual prank or two, but when lives are at stake they are all business.
Unfortunately, the night shift is now under new management and boss Michael Ragosa is more interested in cutting costs than helping people. But T.C. has never met a rule he couldn't break, or a person he won't stand up to. And it's clear that not even Dr. Jordan Santos, T.C'.s ex-girlfriend and now Ragosa's second in charge, has a chance at keeping him in line. If Ragosa wants a war, he'll get one.