The Jay Leno Show premieres with first guest comedian Jerry Seinfeld, and performances by Jay-Z, Rihanna, and Kanye West.

Jay interviews director Michael Moore; the "10 at 10" segment is launched by Tom Cruise and Cameron Diaz; and Jay makes some house calls at 10 PM.

Robin Williams joins Jay as his guest. Also, Miley Cyrus takes part in 10 at 10, plus a correspondent reports about "Ghosting to America," from the Australian comedy duo of Hamish and Andy.

Halle Berry, Tom Papa, Bruce Hornsby & Eric Clapton

Drew Barrymore goes for a ride on Jay's new racetrack. Also, Jim Norton's first submission as a correspondent "Jay Walking."

Guests include actress Jennifer Gardner, Rep. Barney Frank, along with the current news headlines.

Jay's guests includes Pee Wee Herman, plus 10@10 with Amy Poehler.

Guest include actor Vince Vaughn; Al Michaels and Bob Costas compete on a race track; and the first report from correspondent Marina Franklin.

Jay welcomes Rush Limbaugh to the stage, and singer Smokey Robinson w/ Joss Stone.

Hugh Laurie, LeBron James

Jays guests include comic Bill Maher, and singers Brad Paisley & Sheryl Crow.

Jay's guests include actress Julia Louis-Dreyfus and comedian/actor Billy Crystal.

Jay welcomes comedian Adam Carolla, actor Steve Carell and singers Vince Gill & Emmylou Harris to the stage.

Comedian/actor Chris Rock is Jay's guest.

Jay welcomes actress Jenna Fischer and comic Dan Ahdoot, to his show.

Jamie Foxx, Joe Torre

Abigail Breslin, Tim Allen

Comic Wanda Sykes and Kathleen Sebelius, Secretary of Health and Human Services, are Jay's guests.

Jay welcomes actors Gerard Butler and Jack Black along with singer Ben Harper.

Jay welcomes Terry Bradshaw as his guest.

Comic Dana Carvey; singer Justin Timberlake are Jay's scheduled guests.

Jay's guests include actor John C. Reilly and professional football player Ben Roethlisberger.

Correspondent Mikey Day, comic Bill Cosby and singer Toby Keith join Jay.

Matt Lauer, Jeff Dunham

Ross Mathews, Sen. John McCain

TBA

Martha Stewart, Ludacris

Rainn Wilson

Hilary Swank, Jerry Jones

Colin Firth, Michelle Obama

Dr. Phil McGraw

Ewan McGregor, Tina Fey

Chelsea Handler, Brian Williams

Paula Abdul

John Cusack, Frank Caliendo

The Jay Leno Show welcomes comedians Hamish and Andy, singer Mariah Carey and a performance by Cirque du Soleil.

The Jay Leno Show welcomes California Governor Arnold Schwarzenegger, Katie Featherston and Micha Sloat.

The Jay Leno Show welcomes former First Lady Laura Bush, Jenna Bush Hager and correspondent Mikey Day.

The Jay Leno Show welcomes comedian Wanda Sykes, talk show host Rachael Ray and correspondent The Dan Band.

The Jay Leno Show welcomes actress Elizabeth Banks.

The Jay Leno Show welcomes actor Dane Cook and writer Diablo Cody.

The Jay Leno Show welcomes the latest castoff from "The Biggest Loser".

The Jay Leno Show welcomes actress Sandra Bullock.

The Jay Leno Show welcomes actress Penelope Cruz and singer Dolly Parton.

The Jay Leno Show welcomes actor Terrence Howard and former NFL quarterback Terry Bradshaw.

The Jay Leno Show welcomes actor Taylor Lautner and actress Heather Locklear for 10 at 10.

The Jay Leno Show welcomes Tyra Banks, the latest castoff from The Biggest Loser and correspondent Arsenio Hall.

The Jay Leno Show welcomes comedian Larry the Cable Guy and correspondent Mikey Day.

The Jay Leno Show welcomes actress Dakota Fanning.

The Jay Leno Show welcomes actor Jay Mohr

Jay's guests are Gov. Arnold Schwarzenegger of CA. and Lady Gaga who will perform.

Jay's guests are basketball great Charles Barkley and the latest eliminated contestant from The Biggest Loser.

Jay's guest is actress Paula Patton.

The Jay Leno Show welcomes actress Megan Fox.

The Jay Leno Show welcomes correspondent Adam Carolla.

The Jay Leno Show welcomes actor Tim Allen.

The Jay Leno Show welcomes comedian Dane Cook and reality TV star Kim Kardashian.

The Jay Leno Show welcomes actor Morgan Freeman and musical guest Maxwell.

The Jay Leno Show welcomes actor Kelsey Grammer and musical guest Taylor Swift.

The Jay Leno Show welcomes actress Susan Sarandon, and Andrea Bocelli with the Muppets.

The Jay Leno Show welcomes actress Gabourey Sidibe and the winner from The Biggest Loser.

The Jay Leno Show welcomes director Quentin Tarantino, and New Orleans Saints quarterback Drew Brees for 10 at 10.

The Jay Leno Show welcomes actor Matt Damon and singer Barry Manilow.

The Jay Leno Show welcomes chef Gordon Ramsay.

Jay's guest is director James Cameron.

Jay's guests are actress Christina Applegate and singer Nick Lachey.

Jay's guests are Sigourney Weaver, John Mayer, and Correspondent Mikey Day.

Jay's guests are actor Sam Worthington and singer Mary J. Blige.

The Jay Leno Show welcomes TV host Glenn Beck and former reality star Kate Gosselin.

The Jay Leno Show welcomes comedian Tim Allen and Jersey Shore's Nicole "Snooki" Polizzi.

The Jay Leno Show welcomes fitness expert Jillian Michaels and reality show star Kim Kardashian.

The Jay Leno Show welcomes actor Hugh Jackman and news anchor Katie Couric.

The Jay Leno Show welcomes actor Denzel Washington, sportscaster Cris Collinsworth, and Mikey Day with JMZ.

The Jay Leno Show welcomes news anchor Brian Williams and comedian Steve Byrne.

The Jay Leno Show welcomes comedian Bill Cosby, and Mike Sorrentino does Ten@Ten.

The Jay Leno Show welcomes actress Sandra Bullock.

The Jay Leno Show welcomes actor Dwayne "The Rock" Johnson and Kourtney Kardashian.

The Jay Leno Show welcomes actor Justin Long and Correspondent Owen Benjamin.

The Jay Leno Show welcomes actress Julianne Moore and Terry Bradshaw.

The Jay Leno Show welcomes actress Emily Blunt and a performance by Ringo Starr and Ben Harper.

The Jay Leno Show welcomes talk show host Chelsea Handler and retired basketball player Michael Jordan does 10@10.

The Jay Leno Show welcomes director James Cameron and Selena Gomez does 10@10.

The Jay Leno Show welcomes actors Billy Crystal and Zoe Saldana.

The Jay Leno show featuring Bad Ads!