Mary is a 44-year-old mature student with achondroplasia, the most common form of dwarfism. Daniel has autism and has been single for two years. Nursery nurse Hayley has never had a serious relationship.
Hayley has Apert syndrome, a rare genetic condition which is characterised by malformations of the face, hands and feet. Hayley is determined to find her Mr Right. Could it be council worker Chris?
Full of energy and with an action-packed life, Mary represented Team GB in the Dwarf Games, winning four gold medals. But Mary has never truly been in love. However, there is one man in her life who is a constant, her 16-year-old son Reece, who also has dwarfism. Will Reece approve of personal trainer Jet, who whisks Mary off for a night of Champagne and ice skating?
Although Daniel's autism makes communication extremely difficult, he finds an outlet in his songs, many of which are about love and his desire for a girlfriend.
After careful practice and preparation, Daniel goes on a date with Hollie.
The dates this time include John, who hopes to put his Asperger's to one side and meet his first ever girlfriend. There's also bisexual jazz singer Ruth, and the incurably romantic Zoe.
Twenty-one-year-old John has Asperger syndrome, which, for him, means he struggles to understand how relationships work and makes him prone to anxiety. But if meeting the women from the dating agency makes him panic, how will he cope on an actual date?
Ruth is a 27-year-old jazz singer from north London. Charismatic and talented, she's looking for someone to form a meaningful relationship with, but her Tourette's syndrome can make dating tricky.
Will 29-year-old bar manager Dan or 24-year-old film industry worker Jen be the man, or woman, for Ruth?
Zoe is 24 years old and has a very rare condition called Mosaic Down syndrome which affects only 2% of people with Down's.
Zoe spends her days dreaming of her perfect wedding.
Will her date, 31-year-old Nsimba, be the future husband Zoe has been hoping to meet?
This episode catches up some memorable daters from previous episodes, including incurable romantic Kate has always dreamed of meeting her future husband.
Last year Kate turned to a dating agency for help, and was set up on a blind date with Simon. Twelve months later and Kate and Simon are still going strong.
Twenty-seven-year-old Michael has recently hooked-up with Jennifer, who he's known her for several years, though they've never dated before.
But Michael's autism makes it hard for him to understand the rules of dating and he has a habit of rushing things.
Ray is a 50-year-old office training manager with a learning disability. When Ray met Jeanette, cupid struck, and the couple are still together.
Last time around Brent had just broken up with his childhood sweetheart, but his Tourette's syndrome made it hard to go on dates.
And 31-year-old Steve, who has Crouzon syndrome, finds himself back on the dating scene. Will 25-year-old Sophie be the woman for him?
This episode catches up with some memorable daters, including actor Sam, romantic poet Shaine, Richard, who has Asperger's, and self-confessed flirt and local hero Justin, from Rugby.
Previously, part time actor Sam, who has Down syndrome, started a relationship with Jolene, but this ended and now he's re-entering the world of dating.
Shaine hopes his dreams of finding true love can be realised at a poetry class.
Richard meets 35-year-old charity shop worker Lorien.
And Justin, who has neurofibromatosis, a rare condition which causes nerve tissues to grow tumors, goes on his first ever speed-dating event.