In the Arizona desert there is a facility known as CATCH, from where all air traffic in North America is controlled. Scott and Virgil handle a rescue mission involving a mid-air plane collision while Kayo infiltrates the bunker with the help of Thunderbird Shadow. Then Kayo realises that this is all part of a much bigger plan by the Hood.
In the 21st century, Jeff Tracy, a former astronaut, amasses a colossal fortune and decides that he must use it to benefit others. His answer to this desire is to create International Rescue, a unique private emergency response service equipped with customized designed vehicles and equipment that enable the organization to react to any crisis whether it be in sea, air, land, or space.
Jeff's five sons volunteer to operate as the pilots and field agents, as well "Brain" who acts as the teams engineer. In addition, Jeff's friend, Kyrano and his daughter Tanusha aka Kayo agree to be the support staff. In addition to the field team, IR also maintains an intelligence network with Lady Penelope and her ex-con chauffeur, Parker as the chief agents in this arm.