A strange malfunction occurs on a high-speed train in Japan, leaving it out of control and unable to stop. Brains comes up with a plan to fix the problem before a disastrous crash occurs - the only problem is that he will have to board the speeding engine himself to pull it off. Scott manages to get the genius on board, where they find the problem is more complicated than they thought.
In the 21st century, Jeff Tracy, a former astronaut, amasses a colossal fortune and decides that he must use it to benefit others. His answer to this desire is to create International Rescue, a unique private emergency response service equipped with customized designed vehicles and equipment that enable the organization to react to any crisis whether it be in sea, air, land, or space.
Jeff's five sons volunteer to operate as the pilots and field agents, as well "Brain" who acts as the teams engineer. In addition, Jeff's friend, Kyrano and his daughter Tanusha aka Kayo agree to be the support staff. In addition to the field team, IR also maintains an intelligence network with Lady Penelope and her ex-con chauffeur, Parker as the chief agents in this arm.