In Nice, after participating in a prison escape that unfolds in a similar way as the opening scene of the first film, Frank meets Juliette for the first time. Later, Dieter introduces him to his friend Trina, who hires him to deliver a new eco-friendly engine prototype invented by her father on time to the Paris Motor Show. With Trina as his passenger, Frank races towards Paris, but a dangerous hitman, nicknamed "The Wolf", has been hired by automotive and fuel lobbies to eliminate him before he can complete his mission and destroy this major breakthrough. Unfortunately, the prototype, which is installed in Frank's car, emits a GPS signal which does not turn off, enabling The Wolf to easily track Frank and cling to his heels...

Frank's latest job goes completely wrong: he loses his package of drugs in a holdup and is accused by his Russian gangster employer of having embezzled the money. To prove his innocence, Frank embarks on a search for the real culprits and through fancy hotels and rundown buildings the trail leads him to old friends from his SAS unit. The soldiers were attempting to settle a score from the past, by using him as a scapegoat while enriching themselves in the process. But when both they and Frank find themselves in danger from the Russian mobster who's out for blood, they must reconcile and fight side by side - just like old times.

After completing an eventful drop in Marseille, Frank is sent to Berlin, where he is assigned to transport Delia Weigert, a rich young socialite, to a safe house. Her father, a former influential general in the army, has sold off some of his insider military knowledge and Delia is now in grave danger with a German crime lord threatening to kidnap her. With the enemy closing in, Frank must get Delia on a flight back to America, but a sudden betrayal places Delia in deadly jeopardy, and Frank must use all his skills to save her.

While transporting a package, Frank notices the police are on his trail. Ignoring his rules, he opens the package and finds a stolen heart in a cooler, meant for transplantation in a hospital. Frank faces a dilemma when he figures out that his client, Sujic Drago, one of the most powerful crime lords in southern France, stole the heart to save his own son, who suffers from a congenital heart defect, and when Inspector Tarconi informs him that another dying boy is waiting at the hospital for the heart. Should he honor his commitment and deliver the package or return it to its initial beneficiary?

On a mission in Philadelphia, Frank finds out his package is Jack Perkins, his old C.I.A. instructor. The blind man is trying to prove his innocence, while an agency mole is attempting to frame him for leaking confidential information and getting fellow agents unmasked. To save his and his client's lives, Frank has only one solution: find a USB key containing evidence that can clear Jack's name and reveal the real mole's identity...

In Toronto, Frank is asked to pick up a package containing a data stick holding sensitive content implicating a senior industrialist in the African blood diamond trade from a high-security bank vault and bring it to a specific address. Immediately upon leaving the hall he is attacked by a hit squad posing as security guards and finds himself locked inside the building. To make matters worse, an attractive woman security officer falsely accuses him of being responsible for the passing of her colleague, who was caught in the firefight and in order to prevent Frank's escape, she handcuffs him to herself - difficult conditions when you have a hit squad on your tail...

As he's waiting for his package to be delivered in a Toronto parking lot, Frank finds himself faced with a series of strange coincidences. He understands he fell into a trap when the police throws him in jail, accusing him of a crime he didn't commit. His imprisonment is supposed to allow to get a very protected package out of the prison walls: the hand of a mob boss who's just been cuddled...

Frank must transport a million euros from Paris to Marseille while racing against two other elite runners each with the same package and destination. The client whose transporter wins will gain an important missile contract. Word of the race has reached two gangs that decide to try and rob the money but Frank, who needs to prove he's the one and only worthwhile transporter on the market, doesn't intend to let himself be swindled... The task is further complicated by a mysterious hitchhiker, who can not be shaken off and wants to know everything about Frank. Frank manages to end up as the lone transporter to finish the race, but victory is bittersweet, due to the loss of an old friend, who was one of the other two transporters in contention.

Frank is hired to bring a package from the south of France to Paris, which alerts the dogs at a vehicle checkpoint. After being chased by the police and reaching the agreed transfer point, he realizes the package he's delivered is a bomb meant for a planned terrorist attack on the French capital. Frank must rush to find and stop Gassam, the gang leader who'll stop at nothing to avenge his brother, accidentallyhuged during an identity check. After an electric first encounter, Frank can count on Mauga, Gassam's sister, who wants to stop her brother from committing the irreparable while Carla uses her old connections with the French secret service to protect him. The hunt for the bomb begins.

Frank is to pick up a valuable painting from a gallery and bring it to a rich psychopath art collector. There is a wild chase during the transfer and a young woman threatens him with aballoon and claims that the painting is hers. Fortunately, at this moment the police appears and Frank seizes the opportunity to wriggle out of the situation. But when he delivers the painting to art collector Max Khyber, it turns out that it is a fake. Khyber feels betrayed and suspects Frank of stealing the original. He holds Frank prisoner on his property and sends in a dominatrix, Lara, to get him to talk, but Frank manages to free himself and goes in search of the original with the young woman who claims ownership.

Frank has twelve hours to transport a stolen microchip, meant for the development of advanced weaponry, before the rigged packagehugs him. In a race against time, Frank must find a way to force the client to neutralize the deadly device.

Jet, rebellious, young, internationally known and antisocial hacker is Frank's latest package. He delivers her to a trader who speculated with Mafia money and needs her help to reacquire it in the quickest way possible and get his accounts back in order. However the Mafia isn't the only party interested in the young lady, as Frank finds out once his mission his accomplished and he's faced with a very difficult decision: find the hacker again or Carla, who's just been kidnapped, will behuged. Frank discovers that the hacker, who's being accused of spying, actually found evidence of corruption in the DCRI with her best friend, who is now dead in their apartment. Frank enlists Tarconi and Juliette to help him save Carla and the young hacker. But the DCRI proves itself to be a tough adversary...