Peter Parker learns Doctor Octopus has teamed up with Arnim Zola and Hydra to attack the Tri-Carrier, leaving S.H.I.E.L.D. caught off-guard and Spider-Man left to single-handedly stop the assault.

Spider-Man assembles a new team, including an apprehensive Scarlet Spider, in order to stop the villains from taking over New York.

When Doc Ock and Baron Mordo use the Siege Perilous to pull in the Goblin from another universe, Spider-Man enlists the help of Miles Morales and Doctor Strange to try to keep reality from collapsing.

Spider-Man must stop Doc Ock from eliminating Norman Osborne.

Vulture's revelation that Doc Ock has a spy inside S.H.I.E.L.D. Academy leads the Web Warriors on a hunt to find the mole.

Spider-Man and Scarlet Spider must overcome Kraven in order to rescue their kidnapped teammate, Agent Venom.

Spider-Man and Iron Spider discover Doc Ock has taken control of Sandman.

Spider-Man and Agent Venom have been cracking down at defeating possible Sinister Six recruits like Shocker, Grizzly, and Beetle. When Doctor Octopus has made an entirely new symbiote even when Arnim Zola pairs him up with Dr. Michael Morbius, it takes control of Harry Osborn and now forces him to destroy Spider-Man and Agent Venom as the new Anti-Venom. Now Spider-Man and Agent Venom must work with Iron Patriot to free Harry from the Anti-Venom symbiote.

After receiving a mysterious signal from an unknown base, Spider-Man traces it to an abandoned building in the hopes of finding Nick Fury.

Spider-Man faces the culmination of all Doc Ock's evil machinations when the new Sinister Six assaults the Web Warriors and S.H.I.E.L.D. Academy at the Triskelion.

When Doc Ock learns that the key to a device that will retrieve Hydra Island is at Aunt May's house, Spider-Man must fight to protect his family.

When a battered Nova asks for help finding Nick Fury, Spider-Man tracks him to the dangerous ruins of an ancient city.

Spider-Man and Agent Venom discovered Hydra and Morbius' plan to create a new and improved Venom Bomb.

Spider-Man, Captain America and S.H.I.E.L.D. Academy must band together to save New York.

Spider-Man and his fellow heroes have to defeat Morbius and his plan to use the Carnage Queen as a weapon.

Spider-Man and Kid Arachnid travel to alternate dimensions to gather the shards from the broken Siege Perilous.

Spider-Man and Miles, tracking the missing pieces of the Siege Perilous, travel to a tropical Pirate dimension where they meet Web Beard, the Spider-Pirate, and encourage him and his old team to work together to save themselves from the dreaded Kraken.

Spider-Man and Kid Arachnid try to prevent Mr. Negative from using the Siege Perilous to drain all the life and color out of the world.

Spider-Man, having collected all of the shards of the Siege Perilous, returns to Miles Morales' universe and confronts Wolf Spider.

Trick-or-treaters start turning into monsters and Spider-Man, Dr. Strange and Ant-Man must team up to stop Baron Mordo.

Spider-Man must team with the former traitor, Scarlet Spider, to stop Doc Ock from reawakening a secret program designed to create evil duplicates of Spider-Man.

Spider-Man and Scarlet Spider have to infiltrate the sunken Hydra Island so Scarlet can destroy the lab that created him.

Spider-Man puts the Triskelion on lockdown when a mysterious villain begins to take out the heroes one at a time.

Spider-Man house sits on Christmas Eve and is forced to team up with Moon Knight to defend the home from the new Mysterio.

Doctor Octopus threatens to harm Aunt May if Spidey ever puts on his mask again; Spider-Man must track down Doc Ock before he has a chance to put his plan into action.

Peter Parker must find a way to stop Doctor Octopus and the Superior Sinister Six from destroying all of the heroes in New York and taking over the world.