In the aftermath of the events of "Red Sky", Erica goes looking for a scientist who can tell her what the red sky is and learns the horrifying truth about the V's true intentions, On the mothership, Ryan is kept in isolation so Anna can experiment on his new born hybrid baby. After being used by Anna, Chad decides to join the fifth column.

Anna and Diana square off in the dark bowels of the Mothership - Diana has been down there for 15 years and not had a single glimpse of Anna.
Meanwhile, Erica has Tyler's blood analyzed, and learns the V's did something sinister to her when she was pregnant with him.

Erica learns her partner, Malik, is a Visitor and must fight for her life - literally - to stop Anna from finding out she's Fifth Column.
Meanwhile, Anna learns that Malik is missing and orders Ryan to find her, while Lisa realizes her body is beginning to change, causing her to become more and more like her mother.

After the radical faction of the Fifth Column cuddles three Peace Ambassadors, Erica goes on a mission to hunt down their leader, Eli Cohn, a former Mossad agent. Meanwhile, as Jack and other priests around the globe begin to speak out against the Visitors, Anna heads to the Vatican in an effort to convince the leaders of organized religion that the Visitors truly are "of peace".

Anna's latest gift to Earth is "Concordia" but she's really hiding an invasion fleet of breeding vessels. Eli sees "Concordia" as the perfect time to assassinate Anna and sets about convincing the Fifth Column to carry it out.

Anna, enraged at the increasing audacity of the Fifth Column attacks, enlists Ryan in an attempt to wipe out the Fifth Column in one fell swoop. Meanwhile, Father Travis, following Vatican orders, asks Jack to leave the church, and Lisa meets Diana, her grandmother - who Anna said was dead - for the first time.

Erica, seeking revenge against Anna, heads to Hong Kong to carry out a mission to strike a lethal blow against Anna. Meanwhile, Anna learns that Tyler's phosphorous level is too low - even after the Red Rain - and he might become useless to her; and Lisa and Diana bond, beginning to form an alliance against Anna.

Erica prepares the Fifth Column worldwide for a risky attack against Anna. A Live Aboard becomes a major obstacle to Anna's plan to destroy humans. Ryan attempts to rescue his daughter.

The Fifth Column tries to figure out what Anna is planning to do now that she's ready to activate Earth's first Blue Energy reactor. Diana advises Lisa to defy her mother and fulfill her destiny to save the human race.

To ensure the V's evolution, Anna continues to focus on Lisa breeding with Tyler. Meanwhile, both Erica and Diana urge Lisa to save humanity by removing Anna from power. But, even with the help of the Fifth Column, an attempted coup by Lisa has devastating results.