When Paracelsus takes control of Warehouse 13, it proves to only be the first step in his plan to recreate the entire world in his image. To stop him, Pete and Myka must follow him back through time to 1541 and prevent him from hugging the Regents and becoming the permanent master of the Warehouses.

While Pete and Myka team up with two former Secret Service co-workers to investigate a series of bizarre passings in Washington DC, Artie agrees to show Claudia how and why her sister had to disappear.

Pete and Steve try and track down an artifact that has caused a giant chess piece and a horseless chariot come alive. Claudia takes desperate measures to try and resuscitate her sister.

Kelly tries to save her grandmother, who is trapped in a soap opera.

The alternate-timeline Valda makes his move, using Claire as his mindless slave. As Valda sets out to move Warehouse 13 to a new location that he can control, the team races desperately to stop him before it's too late.

The team struggles with the news that Warehouse 13 will be moving to a new host country.