Jackson Oz, an American ex-pat safari guide living in Africa, discovers a link between strange animal attacks on people occurring around the world and his late father's controversial theories about an impending threat to the human race. Meanwhile, journalist Jamie Campbell and veterinary pathologist Mitch Morgan team up to investigate similar abnormal animal behavior in Los Angeles.
Zoo is set amidst a wave of unhappy animal attacks sweeping across the planet. A young renegade scientist is thrust into a race to unlock the mystery behind this pandemic before time runs out for animals and humans alike.