The family receives a $400 phone bill for a phone call to Brazil. Marge and Homer go down to the phone office to get this error corrected, they didn't make the call. Their visit results in their phone service getting cut off. Homer tries to steal phone service, but gets electrocuted for his trouble. Lisa confesses to making the call and tells them of the donations she'd made for an orphan boy named Renaldo in Brazil, with whom she'd lost contact with. The family decides to make a trip to Brazil to find him. The family flies down to Rio, as Maggie takes care of herself, under the watchful eyes of Patty and Selma. They split up with Lisa and Marge looking on one side of town and Homer and Bart on the other. Homer gets kidnapped when he gets into an unlicensed taxi. The kidnappers take Homer up the Amazon. Marge reports the kidnapping to an uncaring police department and Homer tries to raise the $50,000 on his own. Lisa finds Renaldo working for the kids show that Bart has watched with great sexual interest since arriving in Rio. Renaldo is now wealthy, thanks to the new dancing shoes Lisa's donation purchased for him, so he gives Lisa the $50,000 that will let them get Homer from the kidnappers. The transfer is made and Homer is returned, but as we leave our friends in Rio, Bart is celebrating Carnival in the belly of a snake.

After learning the Army used him as a guinea pig for an experimental drug, Bill gets drunk and steals a tank, but Dale reveals that the information is wrong, Bill was not used as an experiment. The guys have to prove to Bill that his life is as it is without military tampering, and get him to surrender the tank.

Scully, Doggett and Reyes investigate an old case that Doggett worked on as a cop in Brooklyn, dubbed "The Screwdriver Killer". They try to determine whether the man who was convicted and has just been released from prison was actually the man responsible for the murders.

When the body of a bisexual young woman is found slain, Goren and Eames note the similarities between her death and a number of murders committed by a convicted serial killer, turning their attention to a human-behavior researcher.

Ruth takes a singular interest in the death of a single woman with no friends or relatives. Brenda, in search of a literary muse, turns to one of her massage clients, a prostitute named Melissa. David's promising relationship with Ben Cooper, a public defender, is thrown for a loop when Keith arrives for comfort, albeit briefly. Claire is disgusted with her friend Parker for getting another girl to take her SATs, and is intrigued when Gary admits there's a "sexual tension" between them. And Nate's relationship with Brenda takes an unexpected turn.

It's days before Lindsay and Melanie's wedding. At a pre-wedding celebration, their friend Leda offers them a tarot reading from Marilyn. Marilyn warns them that they cannot get married on their wedding day because astrological reasons will cause certain disasters to occur. Unwilling to listen to Marilyn, Lindsay and Melanie continue with their wedding plans. However, everything goes wrong: wedding cake is delayed, Lindsay's wedding dress is ruined by the drycleaners, the wedding rings are missing, and the hall that they rented has shut down for salmonella poisoning. Lindsay also has a few panic attacks, and later concludes that these disasters were happening because the world was trying to tell them that they should not get married because they are gay.

At the annual shareholders meeting, Fry meets a 1980s Wall Street power player and ultimately nominates him to replace Professor Farnsworth as the CEO of Planet Express. The new CEO appoints Fry as Vice Chairman and differences are quickly discovered when the strategy is to sell off the Planet Express Company. A mutinous Fry realizes the bona-fide value of the enterprise and attempts to restore the original regime.