While attending a conference in New York, David chases Owen a petty thief into the city's abandoned subway tunnels where he finds an underground community of homeless people. David discovers that some of the inhabitants share symptoms of a mysterious illness and he begins to investigate.

Back at NorBAC, Jill believes that she has discovered a cure for juvenile diabetes from an unsanctioned line of stem cells.

Caroline's nephew Glenn who has been lying in a coma is beginning to show some signs of response.

At the power plant a movie is shown where the workers endorse outsourcing and Mr. Burns announces that he is closing the plant and moving the work to India. Homer is the only union employee left on the payroll and he is sent to India to train the replacement workers, when he succeeds beyond expectations, he is given total control of the plant and declares himself a god. Meanwhile, Selma & Patty take Bart and Lisa to their MacGyver convention. When they discover Richard Dean Anderson doesnt like MacGyver and much as they do, they kidnap him in retaliation. Anderson escapes only to enjoy the thrill and he turns himself back in so that he can escape again. When it happens over and over again, soon Patty and Selma are the ones who need a means of escape.

When Reverend Stroup gives the Hills' pew at the Arlen First Methodist Church to another family, Hank and his family decide to find another church. A slick pastor tries to bribe the Hills into worshipping at his Megachurch.

Nicki suspects that Bill is having an affair and is considering bringing a fourth wife to the family. Margene, feeling alone in the big house, befriends the new neighbor, Pam Martin. Bill goes after Roman and tries to expose him, but polygamy accusations also fly in the Home Plus. Meanwhile, Ben is trying to cope with his arousing sexuality and being a teenager.

Lilly re-opens the 1929 case of a woman found dead in a ravine on Christmas Day when the victim's great-granddaughter comes in asking for help. Meanwhile, Lilly's estranged mother shows up, hoping to re-connect with her daughter.

A schizophrenic living in a halfway house is the prime suspect when the murder of a teenage girl occurs in the neighborhood. Woody and Lu disagree on how to handle the case, but eventually begin to see eye to eye. Macy questions Jordan as she wrestles with the idea of Kayla moving in with her as a foster child. Jordan is frustrated by the lack of support she is receiving from her friends.

Meg becomes an intern for Mayor West. Brian, who is sure that the mayor is corrupt, tries to out him. Brian and Stewie, while undercover, discover that Meg is more than just an intern. Meanwhile, Peter and Lois go back to their folk singing days at a local talent show. When they begin using drugs, Chris stages an intervention.

Logan and Barek investigate after the body of eighteen-year-old violinist Laura Booth is found stuffed in a shaft with her fingers covered with cocaine and resin. Although they initially believe her death may be connected to the cocaine that some of the crew had been transporting, they are soon led to a romantic relationship between the maestro, Julian Reinhardt, and the victim's mother, Gillian Booth.

Johnny Sack seeks permission from the prison to be released long enough to attend his daughter's wedding. Meanwhile, Tony thinks it it time to be on the lookout for some personal protection.

As the polls close and results begin to trickle in, tensions, as well as emotions, fly. Santos and Josh deal with the loss of the Vice Presidential Candidate, and Vinick argues with his campaign team. Meanwhile, the First Lady and Liz Bartlet-Westin eagerly await the results of Doug's campaign for Congress.

Huff is less than pleased with where Teddy choses as his assisted-living facility. Russell ends up asking Huff to give a professional opinion of his new client's behavior. Teddy has a moving moment with Byrd and Beth's mother's health dramatically changes.

A time-traveling jerk wreaks havoc on history. Lion-O, leader of the Thundercats, suffers as an Earth pet. Clifford the Big Red Dog gets in big red trouble. Evel Knievel wows his nursing home. The Swedish Chef "borks" his way through New York City. Corey Haim and Corey Feldman reunite to rescue the President's daughters.

Segment #1 - Doug and his friend are caught searching through a mailbox looking for his friends keys. He is then blamed for putting in a mysterious box without a forwarding address.



Segment #2 - Ne-Yo and his friend come across a bag full of money in an alley but finds out its ransom money, the police ask him where the kid is at and the mother says he took her kid.



Segment #3 - Stephen and his girlfriend are at a tanning salon but when a girl walks by and sees two contruction workers taking pictures, Stephen's girlfriend pushes one of them into a ladder knocking the other guy off. They get accused of hurting a worker and lying about the pictures.

Jason Plato helps a lottery winner choose his dream car with a series of test drives, and Tiff Needell takes the Jaguar XK for a spin in South Africa. Tom Ford reports from the Geneva Motorshow, where he meets Jenson Button, while Vicki Butler-Henderson compares the merits of rally car the Subaru Impreza and the Forester estate on Anglesey.

Jeremy Clarkson takes over as guest host, with guests Antony Costa, Trisha Goddard, Rick Wakeman and Jim Jeffries joining team captains Bill Bailey and Phill Jupitus.