David has less than two days to discover a drug cocktail that will prevent a premature baby from becoming HIV positive. After he discovers a mixture that will save the baby, he encounters a number of bureaucratic roadblocks because the drug has not been approved.

Carlos continues to research the new super strain of HIV with former colleagues in Africa, and realizes that his place is at NorBAC.

Mayko and Simon's investigation of dramatic IQ spikes in children who have been exposed to prion-laced chicken takes them to the United States. They make a brilliant finding but the results are devastating. Meanwhile, Mayko is troubled by some news she discovers about Simon.

Homer spearheads the effort to get pro-football to bring a new franchise to Springfield. The football commissioner, on his way to officially award the franchise, stops at the Simpson house where Grandpa (mistaking him for a burglar) attacks him. Springfield loses out and Abe becomes the towns pariah. After trying and failing assisted suicide, Abe decides to live his life without fear and when the town decides to reuse their football stadium as a bullfighting ring, he volunteers to be the toreador. Ever the activist, granddaughter Lisa protests his new profession.

Buck Strickland embarks on a propane price war with Thatherton and two other rivals, and hires the guys from "American Chopper" to boost sales at the Propane Expo. When the 'war' goes too far, and the companies are all losing profit, Hank takes matters into his own hands, and calls a meeting. Unfortunately, the owners decide to 'price fix' and get caught. Meanwhile, Lucky and Luanne wait for Brownville Station tickets, in line 6 days before tickets go on sale.

Bill goes on a hunting trip with his son Ben, Barb tries to get accredited as a full-time teacher, and shopaholic Nicki realizes she can't pay her credit card bills. Meanwhile, Sarah goes to a house party but ends up needing her friend Heather's help.

The team re-opens the 2002 case of a murdered amateur actor when the owner of a local community theater finds a gun hidden inside prop furniture.

Carlos and Gaby learn the truth about their baby. Libby gives birth to her child, and Gabrielle holds her for the first time. Also, Paul Young comes to face his demons head on with Wisteria Lane. Lastly, Lynette is forced to give a court deposition about Bree's drinking and alcoholism.

Meredith and Izzie take up knitting. Derek operates on Andrew, a spelling bee champ with a serious head injury. Bailey gets in on Andrew's surgery because she's worried that her coworkers won't recognize her Nazi-status now that she's a mother. Addison's patient has an unborn baby with medical issues. After Alex fails to bite his tongue when a terminal patient routinely lies to her daughter about her health he gets a lesson in bedside manners from Burke. George also begins to overstay his welcome at Burke's apartment after Callie visits him. Meredith has more confusing and uncomfortable encounters with members of her family. One of the female doctors meets a veterinarian named Finn. Izzie flirts with Denny and they play more naughty-Scrabble. Meredith, Derek, and Addison sarcastically take another small stab at their friendships.

Huff still feels guilty and angry, and so do his family and friends, about his potentially fatal fight with his best friend, Russell. He Beth's mother is dying and Beth is having a difficult time dealing with it. Izzy and Byrd have become estranged from the family. Meanwhile, Russell takes on a troubled new client, Dauri Rathbun.

No one is happy when it's revealed that Barone Sanitation has been put up for sale. Paulie has a family matter that turns his world upside down. Bobby decides to help out a hopeful rapper by helping him pad his résumé. Tony ends up having a conversation with an evangelical about religion and of all things, dinosaurs.

During the night before Election Day, C.J. is faced with choosing between job offers, Josh stresses over the returns, and Annabeth makes a shocking discovery.

Huff begins his search for Teddy in Mexico, but cannot find him. He ends up being forced to ask Russell, whom he nearly killed and who wants to have nothing to do with him, for help in locating his brother before something drastic happens. Meanwhile, Beth finds that Madeline has taken a turn for the worse and does not know what to do.

Seth Green slimes the [adult swim] creator. He is put into outer space. He comes back. He gets slimed. He is renewed. See what happens when terrorism is used in jokes. A new superhero is in town. "The Six Million Peso Man" is his name. Two space invaders have a little chat. Mr. & Mrs. Brady shows us how The Brady Bunch is involved in the assassin business.

Segment #1 - Rob and his wife stop at a cafe so she can use the bathroom but the people close it while she's in there so she gets locked inside. A good samaritan tries to pry the door open with a crowbar but triggers the alarms. The police acuse him of trying to break in.



Segment #2 - Ashley's fiance is taking him to Griffith Park, when Tiffany's changing in the bathroom a guy jumps into their car claiming a gorilla is chasing him. Just then a gorilla shows up and moments later starts heading towards Tiffany. A zoo keeper is trying to calm it and Tiffany down but then the park ranger threatens to shoot it or anyone in the way.



Segment #3 - Kate and her ex-husband go to a hotel restuarant when a guy starts hitting on her, she tells her ex and he pushes the wrong person into the pool but then the real guy shows up and gets pushed into the pool as well.

Lauren Laverne takes over as guest host, with regular panellists Bill Bailey and Phill Jupitus joined by Fightstar's Charlie Simpson, actress Linda Robson, comedian Rhod Gilbert and Mint Royale's Neil Claxton.