Phoebe and Piper begin to suspect that Billie and Christy are the 'Ultimate Power' that holds the key to bringing Leo back. Meanwhile, Christy begins revealing her true evil colors to Billie, and tries to turn her against the Charmed Ones. Also, Paige must protect her new charge from an angry Darklighter.

While in Cuba investigating the cause of decimated orange groves in Florida, David and Carlos uncover information that points to a possible bio-terrorist plot on the part of the Cubans. The American President jumps the gun and immediately blames Cuba for the damaged crops.

In her search for a cure for Juvenile Diabetes, Jill confirms that the Korean stem cell line is contaminated with a virus. Before her ground-breaking results can move forward, she must prove that the virus is harmless.

Caroline's nephew Glenn fails to respond to his surgery, but does manage one last devastating message.

Bob's attention turns to the escalating danger in the skies over Mexico city, where a massive brown cloud has begun to combine with the toxic emissions from a nearby volcano. The new mixture could rain sulfuric acid down on the city and Bob must try to convince the Mexican officials of the gravity of the situation before all of Mexico City is destroyed.

Homeland Security is monitoring two scientists in Chicago who they believe are a threat to the US President. After taking samples from their lab, David feels the investigation is unwarranted and the two are set free.

Owen shows up at David's office looking for a place to stay.

The family attends "Stab-A-Lot: The Itchy and Scratchy Musical." The musical's director is a graduate of Springfield Elementary and Principal Skinner puts his foot in mouth when he makes sexist comments about her education and that of women in general. He tries to make the situation better, but only buries himself deeper and deeper until he is fired and replaced by Women's Educational Expert Melanie Upfoot. The first thing she does is split the school into girls and the boys. Lisa dislikes the way girls are being taught math and she ventures over to the boy's side of the school in search of a challenge. Disguising herself as Jake Boyman she starts attending the boy's school but while she finds the math problems more interesting, it is being a boy that is a greater challenge.

Instead of getting a job, Bobby and Joseph discover that they can make more money, and look cooler, by hanging out on street corners and begging.

Stan wants Steve to be popular and goes to desperate measures giving him steroids to make him bigger, better, and part of the in-crowd at school. But when the steroids have an unexpected side effect, Steve gets a lot more attention than anyone expected. Meanwhile, after Hayley makes a movie about Francine's life as a housewife, Francine is determined to start a new career as a doctor.

Bill and Roman's disagreements result in lawsuits from both sides as well as unwanted houseguests from the compound. Sarah learns about her family's history from her grandmother and Joey confides in Barb.

The 1945 case of a murdered newspaper reporter is reopened when new evidence suggests that the woman was thrown in front of a passing train by someone she knew.

When Macy tries to deliver some personal effects of a deceased elderly man to his family, he finds a young boy being held captive. When the young boy's deranged captor discovers that Macy knows his secret, he knocks him unconscious and takes him hostage. After Macy awakes, he finds that he has been chained up in the basement. Determined to make it out alive and to rescue the boy, Macy tries to buy himself some time.

Meanwhile, Jordan and Lu butt heads when Lu brings in the morgue's janitor as a suspect in a jewelry-fencing scheme. As Lily's wedding approaches, she is caught off guard when she accidentally runs into Bug on a date.

Gabrielle and Carlos are shocked when the father of their baby shows up to take the baby back. Cops and a lawyer arrive to a house on Wisteria Lane. Lynette tries to help Ed heat up his sex life. Meanwhile, Karl decides to break up with Edie, as Edie has no idea that Susan is the "other woman." Edie causes a fight to break out in a bar, after she trips a waitress. Lastly, Bree is taken a step forward to help Peter when she finds out how bad his other addiction is.

Brian's gay cousin Jasper visits the Griffin house and announces that he is engaged to his partner and wants to be married at their house. When Mayor West bans gay marriage in an effort to cover up and bring attention away from a scandal of his own, Brian resorts to hostile actions to try to change the Mayor's mind. Lois and Peter question their view towards gay marriage while Chris joins the "Young Republicans" Club to impress a girl.

Addison's patient is a Catholic mother of seven who wants her tubes tied secretly. Derek treats a divorce attorney who is having seizures. While Izzie and George are talking about their personal lives they "overhear" part of Derek's conversation with the divorce attorney who calls herself one of Seattle's best. Alex gets in trouble with Addison yet again for not being able to keep his mouth shut when other people think he should. A legendary concert violinist who had a Pacemaker that was installed by Dr. Burke refuses to see medical reason. The musician is Burke's musical hero. Finn cooks for Meredith. Addison and Derek try to re-energize their love life.

Goren and Eames investigate when a respected professional is found murdered in the East River, his death presumably connected to a series of gambling losses.

Tony decides to mull on a real estate deal. A.J. decides that he wants to expand his horizons. Vito is in awe of an act of bravery.

While Santos debates who to choose as his Vice President, Helen has to deal with her new duties as First Lady and new issues the First Family are facing. Meanwhile, Vinick has to figure out what to do now that the election is over.

Sunnyvale is finally going to get some publicity for their new "Convenients Store" and Bubbles "KIttyland" as a TV reporter comes to Sunnyvale. Lahey goes to the dump and finds something surprising. Randy has a new fan.

Huff gets an unexpected visit from his father. Teddy ends up meeting a very attractive young lady while down at the beach. Izzy finds herself arrested on a DUI charge. Beth decides that she will host a meeting of Paula's prayer group. Russell tracks down his young client, who is at a drug house, and then ends up joining in the festivities.

Morning Wood, Idle Nuts, Attack of the Giant Midget, a man catches a mermaid, Bruce Wayne's maid discovers the Batmobile, The Never-Ending Party, Channel 10 News, including Robot Flu, high speed chase, and a porn-eating computer virus.

Segment #1 - Matt Leinart gets accused of solicitating a prostitute but he tries to tell the police that he wouldn't do anything stupid like that a month before the draft. One of the cops tells him to blame his friend and Matt agrees.



Segment #2 - Elijah and his friend drive by a dumpster and Elijah throws a can into it and after driving away from it the dumpster explodes and knocks a huge shelf with paint down onto a car and destroys it. He gets blamed but promises to never smoke in the car again.



Segment #3 - Olivia and her friend try to put a quarter into the parking meter but it won't go in so her friend smacks the meter and it breaks off and they get caught holding it and get charged of destroying city property.

Tiff Needell and Jason Plato compete to find the best super-saloon, pitting the Audi RS4 against the BMW M3 CS. Jon Bentley investigates a fuel-saving scheme, and Vicki Butler-Henderson test-drives the Alfa Romeo Brera, while Tom Ford visits an American club for millionaire supercar enthusiasts.

When a serial dog killer starts stalking Hampstead Heath, the team re-open a 30yr old case and must understand what the killers motives are and why the have re-started killing now.