Clark has second thoughts about Lana marrying Lex, and Lana has the same concerns. Meanwhile, the doctor involved in the secret behind Lana's pregnancy threatens Lex with his knowledge.

Daniel keeps secret from Alexis the fact that he is the one who hired Grace to defend their father, something which Wilhelmina uses to bring the siblings apart. Meanwhile, when invited by Henry to Charlie's birthday party, a desperate Betty asks Dr. Farkas, her orthodontist, to be her date. Finally, Amanda catches the eye of an unusual designer who claims that she is his muse.

J.D. and Turk try to treat Dr. Kelso's uninsured friend. Meanwhile, Dr. Kelso himself is concerned about a clothing thief.

Elsewhere, Dr. Cox tries to convince Elliot that a reformed drug addict isn't exactly clean, and the Janitor blackmails Carla.

Alex grows closer to Jane Doe as he continues to work on her case. Helen Crawford flies into Seattle for surgery. She knows someone on the staff. Colin Marlow enters the race for Chief of Surgery. George faces more problems with Callie and Izzie. Callie reveals a big secret. Someone treats a WWII veteran. Also Derek treats a patient near and dear to him.

Sam and Dean come to the aid of a woman, Molly, who claims that her car went off the road after encountering a ghost. There's no sign of the car, and the brothers take Molly along to hunt down the ghost, as it becomes clear that their encounter with Molly isn't random chance.

10 years after leaving his hometown, Nick Garrett returns to Knights Ridge, to teach a one-day course at Dufresne College, which he believes is a great way to find out what changes since he was gone. After hurting the ones he loved by writing a book, a best-selling novel, and discovering their secrets, Nick will have to find a way to confront past demons and move on with his life. Nick decides to stay after discovering that his ex-girlfriend, Hannah Daniels, has a 10 year old son named Sam who has a peanut allergy... just like all of the men in the Garrett family.

Tonight, actress Sandra Bullock promotes her new movie, Premonition.
Jon begins with a final look at Bush's tour of South America, which ended in Mexico. Jon then talks about Khalid Sheikh Mohamed's confession about planning several terrorist attacks, including 9/11. Jon then talks with Jon Oliver, Senior Produce Analyst, about the Chiquita banana scandal in a segment called "Banana Drama". Chiquita apparently paid $1.7 million in protection money to a Columbian terrorist group. Finally, Jon looks at Iran's outrage over the new movie 300 and how it unfairly disparages Persians.

Tonight Stephen welcomes Somali born member of the Dutch Parliament and author of Infidel, Ayann Hirsi Ali