Betty is in for some wild drama when Marc's mother stops by, given that the latter doesn't seem to know that her son is gay and Betty acts as his girlfriend to help him keep his secret. Meanwhile, Daniel and Alexis are forced to work together when Claire names them both co-editors-in-chief.

Laverne and Dr. Cox engage in a philosophical debate. Carla finds a hot nanny for Isabella, and Turk struggles to find a way not to leer at her.

Elliot smuggles a patient's dog into the hospital to cheer her up and ends up in hot water with Dr. Kelso.

A tragic twist awaits at the end, challenging everyone to decide if they think everything happens for a reason.

Callie's father comes to Seattle Grace and meets George, the hospital starts interviewing candidates for the Chief's position, and Alex helps Jane Doe figure out her place in the world. George and Izzie have a few morning-after symptoms.

While investigating the mysterious death of a lawyer who appears to have been mauled to death by an animal, Sam and Dean realize that they are tracking a werewolf. As they look into the death, Sam becomes attracted to Madison, the victim's secretary, and when it appears that Madison will be the next victim, Sam does all he can to protect her.

Raines and his team have to put the pieces together when a decomposing body shows up in the Venice canals. When they finally identify the victim they find out he is an illegal immigrant and is somehow linked to a Los Angeles Councilman. Raines is sent to see a psychiatrist when the Captain thinks he's acting strange.

Nick decides to stay in Knights Ridge and tries to convince dean Leslie Etwood to give him a job at the local college, but things keep getting in his way. In a way to get back at Nick for leaving years ago, Eddie pursues Aubrey. Ikey isn't pleased to see Alison and Owen on an annual date. Hannah is mad at Nick after realizing The Commander came in the Veterinary Care with a silly excuse, only to find out if Sam is Nick's son or not.

The Obesity Myth, tackles Americas obesity epidemic and examines who really is orchestrating the war against weight.

Tonight, actor Don Cheadle promotes his new movie, Reign Over Me.
Jon first talks about Al Gore testifying in front of Congress about global warming in a segment called "Welcome Back, Hotter". Jon then talks about the fired U.S. Attorney's and Press Secretary Tony Snow trying to sell Bush's offer that Karl Rove testify in private and not under oath in "Showdown at Justice". Finally, Jon talks with Demetri Martin about Viacom suing Google and YouTube over copyright infringment.

Tonight Stephen welcomes the anchor for CBS News, Katie Couric