Hal is sleepless because of their upcoming 20th wedding anniversary. So he ask Reese for some ideas for presents. Then Reese gets the idea to brainwash his dad while he's nervous.
Dewey's friends are set up in an upcoming student body election when a bully nominated two of his geeky friends.
Malcolm takes up playing the electric guitar, though Lois discourages his musical ability. He writes a heart warming song. When he plays & sings his creation, Dewey figures out that his song is sung to the tune of the "Meow Mix" jingle!

The president of the Bluth Company's rival, Sitwell, hires G.O.B. in order to win a softball game against the Bluth Company prompting Michael to ask G.O.B. to throw the game. G.O.B. considers it, but when he finds his new boss fatherly and kind, G.O.B. begins to rethink things. Meanwhile, Lindsay suffers bizarre side effects after taking anti-depressants.

Still not completely convinced of the Avatars good intentions, Piper switches powers with Phoebe in order to experience her premonition of a utopian demon-free world. Sensing their vulnerability during this period, the demon Zankou attacks. Brody's desire to kill all Avatars out of revenge for his parents' death, prompts Paige to take him back to the night they died. Also, the Elders learn that Leo has joined the Avatars, and aren't happy.

David (Peter Outerbridge) and Jill (Sarah Strange) make a trip to Colorado where a rampant SARS-like outbreak is occurring. David is in shock when he discovers that the outbreak is Spanish Flu, the virus he dug up in Nunavut. Racked with guilt, he walks into the path of a car and is sent to hospital in a coma before he tells anybody his fears. Mayko Tran (Mayko Nguyen) heads to Colorado to try to find Patient Zero.

The power plant's office party is being held at the Springfield Air and Space museum, where amongst other things we learn that Agnes Skinner was a wing-walker back in the 1920s. Mr. Burns is acting unusually nice, and then he makes an announcement that the employee prescription drug program has been canceled. Other companies follow suit, the citizens of Springfield

At Springfield Retirement Castle, due to the high cost of medication, they cut their residents off cold turkey. Grandpa goes to his son's home with a plan; he has a friend that will help them out. He and Homer go to Canada where they meet the friend that gives them cards that will let them get all the drugs they can carry. They return home and their drugs are in high demand. Ned and Apu accompany them on their next trip to Canada, but an unfortunate incident with Apu and a hot cup of coffee gets their cover blown as they try to cross the border. They are banished from ever returning to Canada. Because he can no longer afford the medication he requires Smithers' thyroid begins to swell causing a concern for Mr. Burns, he doesn't want to have to train anyone else on his filing system. He provides the means, his old wooden plane The Plywood Pelican, for Homer to invoke his plan to fly into Canada. They load up, but on the return flight the plane encounters trouble. Burns bails out, leaving Homer and Grandpa to crash land the plane in Springfield's town square, where their smuggled drugs are hit. Meanwhile, Mr. Burns has cured Smithers and decides to reinstitute the drug program for all his full time employees. Homer comes home from work to report that he is now a freelance consultant, complete with a lump on his throat.

Cotton inherits $10,000 from the will of his friend Topsy, and goes to Mexico, with Bill in tow, to buy a timeshare. Feeling lonely after the death of his friend, Cotton gets suckered in by tales of the timeshare development's owner, O'Kelly, and decides to buy -- even though Americans cannot own land in Mexico. Meanwhile, Peggy, Bobby and Dale search for a pool to swim in.

When a dying boxing referee makes a confession about a 1976 fight, the team re-opens the case in which an underdog fighter, arranged to fight against a much more qualified boxer, took a heavy beating in the match and died only moments afterwards.

The residents of Wisteria Lane finally learn Martha Huber's fate, and the truth has unexpected consequences for Susan. After learning that Mrs. Huber left behind a journal, Susan is forced to confess to Edie about her role in the fire that burned down Edie's house. Meanwhile Bree finds her new beau, George (Tony Award-winning actor Roger Bart), getting a little too close for comfort. . The receptionist sees Parker's shaven head and believes that Parker has cancer, and allows Lynette's children in the day care, while Lynette does yoga. Lastly, Carlos returns, but his homecoming isn't quite what Gabrielle had in mind. He is under house arrest, making it difficult for either of them to make money.

Lori, along with Denny and Shirley, defends a school superintendent who fired two science teachers because they refused to teach creationism and is now being sued by them. Alan learns his assistant has expressed concern about their work relationship. While dealing with that issue, Alan discovers that his client Bernard Ferrion, who killed his mother, needs legal help again. One of the members of the firm is fired and learns that a close associate is not too keen on lending a supportive hand.

Ben travels on his own to Alamogoro to seek out Father Kerrigan, a former preacher residing in a lunatic asylum, and who knew his father who tells him to beware of a mysterious tattooed man that both Ben and Brother Justin see in their dreams. Back at Carnivale, Stumpy continues his pursuit of Rita Sue and Libby's well being by gambling. Ben finds a distraught Sofie wondering on the road and brings her back to the troupe, while nobody realizes that although Sofie's mother is dead, her ghost (whom only Sofia and see and hear) still lingers around her. Still worried about the missing Lotz whereabouts, Lila looks through his trailer and finds that he couldn't have left at all. Sofie's comes to a decision about where she stands with Carnivale by doing some manual labor, which upsets the other men in the company. Meanwhile, Stroud breaks out of prison to begin his mission for Brother Justin. In Mintern, Justin and Iris start to make groundwork on the location of his latest ministry, the Temple of Jericho, while Dolan continues investigating the Dignity Ministry fire. Also, Justin starts paying late-night visits to Mintern's Chinatown, to a tattoo artist...

With the guilt of his near-miss infidelity weighing down on him, Huff misinterprets Beth's partnership with a young, attractive business client. Russell does the best he can to council his best friend while getting news that puts him in a position where somebody has him by the balls for the first time in his life and there's nothing he can do to change it.