Lois joins a book club to escape the horrors of her home life and Hal frets about how to make the boys behave in her absence. Meanwhile, Francis hitch-hikes through Canada.

Bart is digging a hole in the backyard, which turns into Homer telling a story at Moe's. Moe himself is feeling depressed, he misses his bartending school alma mater, Swigmore University. The guys talk him into going back and Moe leaves Homer in charge of the bar. Back at school Moe meets one of his old professors, who recommend that he reinvent his "crap-hole". Upon his return, the reinvention begins. Now called "M" it becomes an exclusive and Duff-less nightclub. Feeling like outcasts, Homer, Lenny, Carl and Barney set up "a hunting club" in Homer's garage, where there's plenty of Duff and a live band, REM. Moe decides he does not like his new bar and tries to join up with them again. Homer goes turkey hunting and shoots Moe (thinking he is a cougar), renewing their friendship. In the end, the Simpson family, Moe, and REM all celebrate Thanksgiving together.

Sydney goes undercover as a mental patient to meet a guy programed to be an assassin. Meanwhile, Will finds the true identity of the woman who says she had an affair with Danny, and Francie learns that Charlie did not have an affair. Also, Sydney believes that her father killed her mother 20 years ago, and Marshall finds the bug planted by the CIA in SD-6's mainframe.

Doggett catches up with Shannon McMahon, the woman who the EPA official picked up. She claims to be a super solider and that the people she has killed were poisoning the water supply, and she wants Doggett to expose the truth.

The deaths of a reporter and his fiance, gunned down on orders, leads the detectives to investigate political bribery involving the governor's office, which Deakins isn't pleased with.

Why would Toby rather risk expulsion than have his parents there together? Why would Ashley get completely dolled up - just for a bunch of old folks? And that Paige seems to be planning to get in the way again...

"Accusation" is the word of the day, as Richard is convinced Larry stole his answering machine message, while Larry is convinced his plane tickets have been stolen. Later, unfamiliarity with another religion's practices gets Larry in hot water, while getting another out of the water.

Pete and Jo are grilled by immigration officials about their marriage. Adam is made redundant.