Earl goes for number 44 on his list trying to help Pierre, a French foreign exchange student, he made fun of when they went to school together. Earl flies him back to the US and he tries to hook Pierre up with a girl he had a crush on as a child. Meanwhile, newlyweds Randy and Catalina find their marriage changes in ways they would never imagine.

Clark is once again exposed to red kryptonite, and his "other self" goes on a rampage of sorts on Valentine's Day, kissing the women he's most attracted to and expressing his uninhibited feelings for the various relationships around him.

Betty has her job cut out for her getting prepared for Mode's huge event during New York City's Fashion Week. Meanwhile, Marc and Amanda can't delay getting their hands on something everybody desires, Christina wishes to create her mark in the design world and Daniel calls for Hilda to grant her sister a hand.

The hospital is seen through the eyes of Dr. Kelso, who befriends an Iraq War veteran.

The soldier's stay sparks a political debate among staff members.

Nick and Keppler investigate the bizarre world of the black market sales of body parts after they find a body that has been burned and the organs removed. The rest of the CSI team investigates the death of rich woman who was killed in her own home.

The chief's announcement of his retirement sparks competition between Derek, Burke, Addison, and Mark. A surgical patient endangers the lives of those surrounding her. Meredith's mother becomes lucid. Cristina and Callie consider marriage proposals. The Denny Duquette Memorial Clinic opens and Izzie cannot wait for the first patient to arrive.

Taylor concocts a plan to make things right between Ryan and his father. Julie continues to further her relationship with Bullit but when Julie and Frank run into each other in front of Ryan and Taylor it becomes apparent that Julie is having a secret affair with Frank. When Kaitlin finds out that Ryan and Taylor are working to get Julie and Frank together, she goes out of her way to make her mother like Bullit, forcing Julie to choose between Frank and Bullit. Meanwhile, Summer begins to question if Seth is the one for her after she and Seth get a psychic reading.

Michael celebrates Phyllis' wedding shower by bringing two performers into the office: a stripper and a Ben Franklin impersonator. Meanwhile, Karen confronts Pam about her past history with Jim.

The largest real-estate developer in Southern California is gunned down in his Holmby Hills mansion and his disgruntled 16-year-old son is the primary suspect, but the late billionaire had plenty of enemies and was involved in a messy divorce from his trophy wife. Sebastian vigorously investigates the case and Jessica worries that he needs a vacation. At home, Julie gets adjusted to having a personal bodyguard follow her since a suspected serial killer threatened her.

The Winchester brothers look into the murders of several people who say they were visited by an angel and were simply carrying out God's will. After further investigation, Sam and Dean find that those murdered were guilty of secret crimes, but the brothers split on what they think the truth is - Sam believes that there is an angel that caused the murdered, but Dean thinks that a demon is the cause of the deaths. However, Dean soon changes his belief when he sees the unexplainable.

Eddie gets permission from Joy to have a female friend, but it doesn't turn out as she planned when he bonds with her. Meanwhile, Jeff uses Steph to get in with the cool kids at high school.

OCC designs and builds a high-tech chopper for GoDaddy.com, but Jason and Paul Jr. can't agree on a design, so Senior has to step in.

Liz wonders if she's actually on a date with Jack as she accompanies him to a birthday celebration for a foreign prince. While at the ball, Liz sees a different side to Jack as he unexpectedly runs in to his ex-wife. Back at 30 Rock, Tracy tempts Pete with a booze- and babe-filled party in the office, while Kenneth tries to keep Pete on the straight and narrow.

Luka tries to extricate Pratt from a legal mess while Abby, confronted by a vengeful Ames, tries to reach him. Later, Luka finds himself in a tense confrontation with Ames, and Abby must act to protect her family. Neela and Gates rush to get Meg to the hospital. Sams new home is soon under threat from fire, but will everyone escape unscathed?

Marin receives an invitation from Stuart Maxson to join him on an overnight ski trip. Jack accompanies Lynn to the doctor for a sonogram, and Patrick tells Annie that he once made a donation to a sperm bank. Jane and Sam teach each other some of life's secrets, and Buzz meets someone from his past.

Sarah gets arrested for drinking (cough syrup) and driving. After she is released from jail Sarah discovers the attraction between her sister Laura and the arresting officer. Meanwhile Brian tries to convince his partner Steve that he is bisexual.

Tonight actress and star of Factory Girl, Sienna Miller.
Jon first looks at Mary Cheney, the Vice President's lesbian daughter, who stated that the birth of her child should not be used for political maneuvering in response to Wolf Blitzer's interview the day before. Jon delves deeper into the issue as to why Dick Cheney's daughter is off limits with John Oliver, Senior Media Critic. Jon also talks with Chrissy Gephardt, lesbian daughter of former presidential candidate, Dick Gephardt. Finally, Jason Jones exposes the real Orange County in a two-part series.

Tonight Stephen welcomes New York Senator Charles Schumer.

Tom is pleased when one of his favorite bands is to reform to perform at the Midsomer Rock Festival. Leader singer Gary is convinced that somebody is trying to ruin their reunion and his suspicions are confirmed when a member of the band dies.