Clark is in his barn one moment... and the next finds himself in a psychiatric hospital where he discovers he's been suffering from delusions that he came from another planet and has super-powers.

At Keppler's request Catherine uses a different approach to catch the killer, and in doing so she deceives the rest of the CSI team. The team soon discovers that something is amiss in Catherines investigation.

George has become a sex machine. Dr. Bailey has the idea of opening a free clinic. A doctor at Seattle Grace gets proposed to. Addison is avoiding Alex. The Chief officially announces his intention to retire to the administration of Seattle Grace and to Adele. Rumors of Richard's retirement spread throughout the hospital. Two best friends are left with a difficult decision due to an advanced illness. Derek yells at Meredith.

As Kirsten's 40th birthday is nearing, Ryan and the Cohen men prepare a party for her while Kirsten receives news that will forever change her life. Meanwhile, Julie has a secret love affair that Kaitlin tries to stop; and Taylor visits a therapist who gives her advice while Ryan pretends not to miss her. Elsewhere, when the plan to save Newport Chuck falls through, Che finally learns that Seth is not his soulmate.

Sam and Dean investigate a string of robberies with disturbing similarities. In each robbery, a top-notch employee holds up and robs the business and then commits suicide. The Winchesters discover that a shape shifter is at work and try to get ahead of it at the next business it intends to hit: a bank.

The design contest between father and son continues, with fans picking the winner. Paul Sr. goes old school while Jr. puts together a new spider-web design.

While Marin moves into her rustic mountain cabin and finds some unexpected visitors, Jane unintentionally neglects Sam. In the meantime, Sara fills in at the Chieftain as Theresa takes care of Ben. Patrick is concerned he will not be able to give Annie the wedding of her dreams, and Celia admits she is dating her boss.

Tonight New York Senator Charles Schumer.
Jon begins with a look at Senator John Kerry's long winded speech about how he is not running for President. Finally, Jon looks at Wolf Blitzer's interview of Dick Cheney and his lack of commenting on anything, specifically how he refuses to answer any question about his lesbian daughter.

Tonight Stephen welcomes senior 60 Minutes anchor Mike Wallace.

When a new glass ware business faces ruin, the team have to investigate the murder of it's accountant.