The authorities led by Dennis Hyland wants to quarantine every 4400, as several of them are sick with the same as Maia. Hunted by bad conscience Kyle somehow contacts Marsden's girlfriend.

The drama about a Los Angeles funeral home meets its maker after five compelling seasons. Three weeks ago, Nate Fisher Jr'.s death ended speculation about which of the show's major characters would die. But in the hands of creator Alan Ball, who wrote and directed this episode, you can bet the finale will be anything but anticlimactic. One issue certain to be resolved involves the health of Nate's unborn child, since tonight, Brenda goes into labor. While the last two seasons have been downbeat, the writing has remained original, the acting terrific. Like Nate, the series will be missed.

When a hardcore drug dealer brutally murders an FBI Agent, Fugitive Task Force member Eddie Drake volunteers to go deep under cover to keep him from killing again. But, as Drake loses himself in the role, he finds himself being pulled into a world he might not be able to escape. Meanwhile, when faced with a tough decision, will Conrad choose to give up on his family?

Valerie is pleased as spiked punch when "Room and Bored" gets nominated for a People's Choice Award. After a rigorous fast and a painstaking wardrobe selection, Valerie is ready to make a big impact on the red carpet... if only the paparazzi will oblige.

Johnny tags along with Sarah on a visit to a Cleaves Mills retirement community where Sarah's father has recently moved to. While at the retirement community, Johnny has a disturbing vision which makes him suspect something strange is going on there. He finds that the residents are dying at an unusually high rate, and that there are whispers among the old folks about a Shadow Man who has been creeping around the hallways in the middle of the night and snatching people's souls. Johnny must find out what this Shadow Man truly is before it can claim any more victims, including Sarah's father's. Also, Sarah worries that her father will die before they can settle their differences, and JJ connects with his grandpa in a profound way.

When Vince misses an appointment for his physical because he is spending time with Mandy, Eric and Ari start to worry Vince's love life is interfering with business, and Mandy's talent managers have similar concerns. Turtle and Drama do some detective work after they recover Eric's stolen Maserati, which leads them to a musical discovery that turns Turtle into an agent. Turtle strikes a deal with Billy Walsh for the Queens Boulevard score and is convinced his new client is headed for superstardom.