On the heels of discovering that NTAC is behind the disease plaguing the 4400, Tom and Diana find themselves enveloped in a government conspiracy to hide the truth. Although the disease was an unforeseen side affect of an inhibitor secretly administered to the 4400 to prevent the emergence of special abilities, it's clear that the powers that be are more concerned with covering their tracks than curing the disease. Now Tom and Diana must face off against their own agency as they race against time to get to the bottom of NTAC's coverup and help find a cure before it's too late.

Eager to return to Rome after eight long years of war, Gaius Julius Caesar ends his campaign with a resounding triumph in Gaul, and news of a shattering personal loss at home. In Rome, Caesar's old friend Pompey is counselled by the Senate, who worry about Caesar's growing popularity. Two soldiers are enlisted to find the army's stolen gold standard. Atia is careful to play both sides of an escalating power struggle.

The Fugitive Task Force races against the clock to apprehend a psychotic child killer after he escapes from a mental hospital and abducts another victim. As Connie and the team go after the killer, Jimmy McGloin is haunted by an event from his past that could compromise the investigation. When his daughter goes missing, Connie faces a nightmare of his own.

Jane pulls rank on Tom and Paulie G. to get Valerie more lines on "Room and Bored". A stalker threat forces extra security on the set, exposing Valerie's old back problems as she's prepping for a big pratfall scene.

Johnny has a vision of Stillson begging him for help with finding his girlfriend, and when his vision comes true, he must decide whether it's really worth it or not to help out his enemy. Johnny's decision is further complicated by another vision in which he sees a better future which may be the result of him refusing to help Stillson.

While Vince is caught up being in love with Mandy, she is caught with her ex-fiance. Ari's scheming at the agency backfires, leaving his future uncertain.