Jill and the U.S. National Guardsmen begin to recover after receiving the lethargica antidote; but shortly thereafter, the Guardsmen begin to fall ill again with a secondary more deadly infection. Some Guardsmen begin to die and everyone fears for Jill's life.

Caroline believes that her superiors aren't telling her everything about the lethargica outbreak and suspects that Wes, her executive assistant might also be in on it.

Out of nowhere, the Manford brothers show up at David's apartment and shed some light onto the recent epidemic.

As Caroline continues to dig, she gets dangerously close to unearthing a conspiracy that could go deep into the White House.

Ryland and other government officials are on trial for withholding vital information that they discovered about the returnees when a disturbing sound is heard the courtroom. Tom and Diana, with the help of Gary Navarro, try and track down T.J Kim, who they believe is responsible for the piercing sound heard in the courtroom. Richard and Lily are forced to deal with a now grown Isabelle While Lily also suffers from a rapid aging disease that Shawn is unable to heal. Tom and Diana also investigate a radical organisation called the Nova Group that appears to have ties with Shawn and the 4400 Center.

Gary Navarro is arrested for the second attempt to assassinate Dennis Ryland. Knowing she is the key to her mother's survival, Isabelle attempts to kill herself by jumping off the 4400 center building only to survive without a scratch. Matthew Ross expresses his displeasure at her actions and tells her of the destiny she is to face. Isabelle is troubled about what Matthew told her, but after a discussion with Shawn she decides it's her choice with what she does with her life. Matthew gives Isabelle a substance that can kill her if it's injected.

Deadwood's first true elections are nearly here, with the offices of sheriff and mayor to be decided. Tonight, the candidates will state their cases to the townspeople. One of Hearst's Cornish workers is killed at the Gem, leading Swearengen to suspect that the incident was a staged Hearst power play. Ellsworth and Doc Cochran are alarmed by complications involving Alma's pregnancy. Star gains a new home from Adams' orchestrated foreclosure. Jane prepares to tell the camp's children about her experiences scouting for General Custer. Shocked by her inability to make a clean break from the gut-stabbed Tolliver, Joanie considers taking the easy way out. Hearst will give Bullock his political backing if Bullock promises to exert influence over certain areas of the camp.

As the gang anticipates the upcoming premiere for "Aquaman", the search is on for a perfect date for Vince. Meanwhile, Ari tries to cope with financial difficulties and his new office space, which is not quite what he is used to.

Beth is shocked when Izzy offers to help her in her time of need. Byrd and Eli decide to get even with James for all he has done. Huff and Russell hit the town.

Paris and Nicole trade in their designer dresses for traditional saris when they take over the responsibilities of a traditional Pakistani mom. With the patient help of their "husband" and Americanized fifteen-year-old "son", the girls manage to dress, speak and dance like conservative Pakistani housewives... or at least their version of it. But things don't go as well when Paris and Nicole decide to share their experiences, namely how they like to party.

Louie works part time at the local muffler shop while his wife Kim works works as a nurse at the hospital and runs the household. Louie begins to wonder if his wife wants another baby when she tries to seduce him out of the blue. Meanwhile, Walter is upset at Louie's friendly gestures.