After claiming the Book Of Shadows, Zankou prepares to open the Nexus, and claim its power. In a last ditch effort to stop him, the sisters goad him into coming after them instead. Undaunted, Zankou steals Phoebe's powers, and is able to anticipate the Halliwells' every move. Also, the law enforcement investigation into the sisters ratchets up a notch.

The discovery of nine human skulls leads Rush (Kathryn Morris) back to George Marks, the serial killer she was unable to incriminate months earlier, and who walked away a free man. As the detectives reinvestigate his mother's murder from 1972, George is forced to emerge from hiding to face Rush again. This time, their very lives are at stake in their final showdown.

Swearengen's shrewd manipulation of the rumor mill pays off in a Yankton counter-offer that requires only slight amending. Meanwhile, George Hearst's arrival in Deadwood has shaken up the camp's status quo from Wu to Farnum to Wolcott. Tolliver, for his part, seeks to avoid marginalization by offering the tycoon damning nuggets about his engineer's nasty habits.

Gabrielle, Susan, and Lynette rush to the hospital in the middle of the night after receiving a phone call from Danielle telling them about Rex's heart attack. Bree confides that she feels guilty because she and Rex were having a fight when he had his heart attack and that now he needs a pacemaker. Before his operation, Rex apologizes for being a bad husband. After not getting any better, the doctor suggests to Rex that maybe Bree was tampering with his medication. Rex writes her a note telling her that he understands, and then dies not knowing the real truth. Minutes later, a doctor calls Bree to tell her that Rex has died. She numbly sits in her empty dining room, looking at the chair where Rex would normally sit. She goes into typical Bree coping mode by polishing the silver but then she dissolves into heartbroken sobs. Lynette's marriage takes a dramatic turn after an upset Tom, who accidentally quit his job under false pretenses due to Lynette's manipulation, vows that it is now her turn to go back to work and he'll be staying home with the kids. And Lynette may just take his offer. Carlos finally learns that John and Gabrielle have been lovers for a while, and vows revenge as he is carted off to jail. Mike takes Paul out to a deserted quarry, intending to shoot him. After realizing it's about Dierdre, Paul reveals why Mary Alice killed herself: a drugged-out Dierdre sold them her baby to feed her habit. They fled Utah and changed their names, but she still found them. Mary Alice killed Dierdre by accident when she came to forcibly take Zach/Dana back from them and they hid her body where they thought it would never be found -- in a toy chest buried under their new pool. In the end Mike doesn't kill Paul, but goes home where Zach is waiting for him, while pointing a gun at Susan.

A sexually transmitted disease breaks out and affects several members of the hospital staff. Chief Webber promptly calls a meeting. Meanwhile, the chief reluctantly tells Dr. Derek Shepherd about his own medical concerns. Izzie and Cristina worry about a patient's wife and daughter who can't agree on his care. Burke treats his college buddy Bill, whose medical diagnosis raises some questions regarding his wife's actions. Then just as Meredith and Derek grow more intimate, a surprise is revealed.

The boys star in another one of J-Roc's greasy porn films. Randy and Lahey manage to get Ray arrested for disability fraud.

The Gang is back!! Michael plans a party that doesn't go quite as planned. Justin makes a decision that will effect his future with Brian and Brian makes a sound investment in a new business venture with Ted's encouragement.

Times are changing on Liberty Avenue. Justin returns and Brian re-opens Babylon. Michael makes a major decision regarding his daughter while Emmett gets a new job. Ted becomes the center of attention and makes some changes to his appearance.

In "Ding Dong, King Kong." A famous monkey breaks out of its cage, a Hollywood News and Gossip gets a nastly treament. The Smurfs are scrambling to find the one behind a string of serial killings in the village, killings that are mimicking the seven deadly sins.

Coming Soon...

The team re-examine the case of Hannah Taylor who was kidnapped from her home in 1992. A body, previously thought to be Hannah's, has just been identified as that of another kidnap victim.