It's been one year since the 4400 returned. After a period of intense medical observation, Tom has returned to NTAC in a limited capacity, assigned only to desk duty. Diana, having been through a series of inept partners, finally finds a way to cut through the red tape and get Tom back, all while in the midst of formally adopting Maia. Meanwhile, Richard, Lily and the baby are still living in meager conditions in a mountain cabin far away from Jordan. Jordan has now closed Arcadia Estates, and is on the verge of opening 'The 4400 Centers', a place for non-members of the 4400 to discover 'the 4400 within themselves'. Collier becomes Shawn's guardian, and enlists him to heal important benefactors of the Centers.

It's been one year since the 4400 returned. After a period of intense medical observation, Tom has returned to NTAC in a limited capacity, assigned only to desk duty. Diana, having been through a series of inept partners, finally finds a way to cut through the red tape and get Tom back, all while in the midst of formally adopting Maia. Meanwhile, Richard, Lily and the baby are still living in meager conditions in a mountain cabin far away from Jordan. Jordan has now closed Arcadia Estates, and is on the verge of opening 'The 4400 Centers', a place for non-members of the 4400 to discover 'the 4400 within themselves'. Collier becomes Shawn's guardian, and enlists him to heal important benefactors of the Centers.

Stan invites his boss over for dinner, but the Smith family fears getting caught hiding Roger. After a close-call, Roger goes into a coma, making everyone thinking he's dead. After the family disposes of his body, Roger tries to get back home, but he ends up in another risky situation with the CIA.

When Meg gets turned down for a date, she asks her family for support. Lois ends up taking her to the mall, where she gets the ultimate makeover. Meanwhile, Peter tries to start a band with the guys, but when their first gig fails, the family ends up performing. Impressed by Meg's singing, a record producer signs the family, and their travels eventually land them on "Saturday Night Live."

Julian's biggest money-making scheme yet involves smuggling drugs in shopping carts. Ricky lets Trinity drive the shitmobile and she gets arrested.

Valerie wants a role in a new sitcom pilot called "Room and Bored", about four hip singles living in a condo, but can only get it if she allows cameras to follow her for a reality show. She lands the part but soon discovers that it's not the one she was expecting.

Brian's beliefs regarding marriage haven't changed. Debbie has difficulty adjusting to retirement and Ted decides to make some drastic changes in his life.

The guys are back from New York and Ari is already pushing a commercial project, Aquaman, at Vince but he isnt buying it. Eric has an official title now, but when he has to make a sex date with Kristen, his status is questioned. Turtle is cranky about his new job and takes multi-tasking to a new chaotic level.

Sailor Moon encounters a bone-chilling villain. A nerd wins a date with famous actress Scarlett Johansson. "Welcome to the Terrordrome" showcases inner-office machinations at the headquarters of G.I. Joe's nemesis Cobra. "America's Most Tragic Home Videos" will make you laugh and cry.

Attractive widow and probate assessor Elise Allen asks Halford to find the rightful owner of a large, uncut red diamond, worth 15 million. She found the rare jewel in a flat rented by John Newman who died in 1982.